Methods for the identification of antimicrobial compounds
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United States of America Patent
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May 4, 2004
Grant Date -
Nov 28, 2002
app pub date -
May 25, 2001
filing date -
May 25, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to methods to assay 2-amino-2-deoxy-D-glucose-6-phosphate ketol-isomerase activity. The present invention also relates to methods for drug screening to identify compounds having antimicrobial activity, wherein the compounds have the ability to inhibit the enzymatic activity of a microbial ketol-isomerase. In other embodiments, methods are provided for the identification of compounds that selectively inhibit microbial ketol-isomerase activity compared to the ketol-isomerase activity of the subject being treated for an infection.
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