Multiparticulate bisoprolol formulation
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United States of America Patent
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May 11, 2004
Grant Date -
N/A
app pub date -
Jan 20, 2000
filing date -
Jan 21, 1999
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A multiparticulate bisoprolol formulation for once-daily oral administration, each particle of which comprises a core of bisoprolol or a pharmaceutically acceptable salt thereof surrounded by a polymeric coating, the polymeric coating being effective to achieve an initial lag of bisoprolol release in vivo of at least 4-6 hours following administration and thereafter maintaining therapeutic concentrations of bisoprolol for the remainder of the twenty-four hour period. The formulation can be used for night-time dosing so as to minimize the likelihood of acute cardiovascular occurrences in the well-documented high risk period in the morning.
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