Bioconjugation of macromolecules
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United States of America Patent
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May 18, 2004
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app pub date -
Jul 8, 1999
filing date -
Jan 8, 1997
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Abstract
This invention discloses a novel method for conjugating macromolecules to other molecular entities. Specifically, this invention discloses a method for conjugating or derivatizing macromolecules, such as oligonucleotides and proteins, using cycloaddition reactions, such as the Diels-Alder reaction or 1,3-dipolar cycloadditions. Included in the invention are the novel bioconjugated macromolecules that can be prepared according to the method of the invention.
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