Methods for the identification of fungal glucose utilization inhibitors and antifungal agents
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United States of America Patent
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Jun 1, 2004
Grant Date -
Oct 16, 2003
app pub date -
Aug 10, 2001
filing date -
Aug 10, 2001
priority date (Note) -
Expired
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Abstract
The present invention provides methods for simultaneously assessing microbial phosphoglucose isomerase, ketol-isomerase and glucosamine-6-phosphate acetyltransferase activities, by measuring the production of Coenzyme A (CoA). The present invention finds use in the isolation of new classes of antifungal drugs, wherein the compounds have the ability to inhibit fungal glucose utilization.
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