Thiol sulfonamide metalloprotease inhibitors

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 6747027
SERIAL NO

08898175

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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This invention is directed to proteinase (protease) inhibitors, and more particularly to thiol sulfonamide inhibitors for matrix metalloproteinase 13(MMP-13), compositions of proteinase inhibitors, intermediates for the syntheses of proteinase inhibitors, processes for the preparation of proteinase inhibitors and processes for treating pathological conditions associated with pathological matrix metalloproteinase activity related to MMP-13.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
MONSANTO COMPANYST LOUIS, MO294
PHARMACIA CORPORATIONST LOUIS, MO18

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abbas, Zaheer S Chesterfield, MO 2 2
DeCrescenzo, Gary St. Charles, MO 14 3
Freskos, John N Clayton, MO 143 1208
Getman, Daniel P Chesterfield, MO 158 1014
Heintz, Robert M Ballwin, MO 63 494
McDonald, Joseph J Ballwin, MO 67 322
Mischke, Brent V Defiance, MO 14 71

Cited Art Landscape

Patent Info (Count) # Cites Year
 
MONSANTO COMPANY (1)
6013649 Thiol sulfone metalloprotease inhibitors 17 1997
 
MERCK SHARP & DOHME LTD. (1)
5472978 Aromatic compounds, pharmaceutical compositions containing them and their use in therapy 14 1993
 
Warner-Lambert Company (1)
* 6297247 Sulfonamide inhibitors of matrix metalloproteinases 4 2000
 
JOHNSON MATTHEY PHARMACEUTICAL MATERIALS, INC. (2)
5475138 Method preparing amino acid-derived diaminopropanols 29 1994
5599994 Amino acid-derived diaminopropanols 7 1995
 
BRITISH BIOTECH PHARMACEUTICALS LIMITED (1)
5451676 Biphenyl ether heterobicyclic platelet activating factor antagonists 5 1993
 
G. D. Searle & Co. (1)
4595700 Thiol based collagenase inhibitors 56 1985
* Cited By Examiner

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
VERTEX PHARMACEUTICALS INCORPORATED (2)
* 7485664 Inhibitors of TACE 1 2003
* 2004/0186,088 Inhibitors of TACE 2 2003
 
FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (2)
8404866 Substituted heterocyclic mercaptosulfonamide metalloprotease inhibitors 0 2009
* 2011/0144,179 Substituted Heterocyclic Mercaptosulfonamide Metalloprotease Inhibitors 0 2009
* Cited By Examiner