US Patent No: 6,749,740
Number of patents in Portfolio can not be more than 2000
Small volume in vitro analyte sensor and methods
Stats
-
Jun 15, 2004
Issued date -
Dec 28, 2001
filing date -
10/033,575
serial no -
In Force
status
Importance
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Abstract
A small volume sensor, and methods of making, for determining the concentration of an analyte, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. The sensor includes a working electrode and a counter electrode, and can include an insertion monitoring trace to determine correct positioning of the sensor in a connector. In one embodiment, the sensor determines the concentration of the analyte by discharging an amount of charge into the sample, determining the time needed to discharge the charge, and determining the current used to electrolyze a portion of the analyte using the amount of charge and the amount of time.
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First Claim
Related Publications
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International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art
| Patent Info | (Count) | # Cites | Year |
|---|---|---|---|
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| 4,224,125 Enzyme electrode | 374 | 1978 | |
| 4,392,933 Electrochemical measuring apparatus comprising enzyme electrode | 168 | 1982 | |
| 4,897,173 Biosensor and method for making the same | 343 | 1987 | |
| 5,120,420 Biosensor and a process for preparation thereof | 479 | 1989 | |
| 5,229,282 Preparation of biosensor having a layer containing an enzyme, electron acceptor and hydrophilic polymer on an electrode system | 268 | 1990 | |
| 5,266,179 Quantitative analysis method and its system using a disposable sensor | 493 | 1991 | |
| 5,185,256 Method for making a biosensor | 218 | 1991 | |
| 5,192,415 Biosensor utilizing enzyme and a method for producing the same | 300 | 1992 | |
| 5,582,697 Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same | 385 | 1995 | |
| 5,565,085 Method for quantifying specific compound | 146 | 1995 | |
| 5,575,895 Biosensor and method for producing the same | 291 | 1995 | |
| 5,650,062 Biosensor, and a method and a device for quantifying a substrate in a sample liquid using the same | 291 | 1995 | |
| 5,651,869 Biosensor | 195 | 1996 | |
| 6,004,441 Biosensor | 198 | 1997 | |
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| 5,128,015 Method and apparatus for amperometric diagnostic analysis | 231 | 1989 | |
| 4,999,582 Biosensor electrode excitation circuit | 167 | 1989 | |
| 5,108,564 Method and apparatus for amperometric diagnostic analysis | 301 | 1991 | |
| 5,352,351 Biosensing meter with fail/safe procedures to prevent erroneous indications | 345 | 1993 | |
| 5,413,690 Potentiometric biosensor and the method of its use | 223 | 1993 | |
| 5,589,326 Osmium-containing redox mediator | 170 | 1993 | |
| 5,437,999 Electrochemical sensor | 472 | 1994 | |
| 5,438,271 Biosensing meter which detects proper electrode engagement and distinguishes sample and check strips | 254 | 1994 | |
| 5,846,702 Reagent including an osmium-containing redox mediator | 120 | 1996 | |
| 5,857,983 Methods and apparatus for sampling body fluid | 272 | 1997 | |
| 5,879,311 Body fluid sampling device and methods of use | 273 | 1997 | |
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| 5,168,046 Method for determination of glucose concentration | 103 | 1990 | |
| 5,272,060 Method for determination of glucose concentration in whole blood | 108 | 1992 | |
| 5,382,346 Biosensor and method of quantitative analysis using the same | 251 | 1993 | |
| 5,496,453 Biosensor and method of quantitative analysis using the same | 347 | 1994 | |
| 5,589,045 Data managing method in portable blood sugar value-measuring and portable blood sugar value-measuring apparatus using same | 97 | 1994 | |
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| 5,781,455 Article of manufacture comprising computer usable medium for a portable blood sugar value measuring apparatus | 137 | 1996 | |
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| 5,264,106 Enhanced amperometric sensor | 239 | 1993 | |
| 5,727,548 Strip electrode with screen printing | 281 | 1995 | |
| 5,628,890 Electrochemical sensor | 563 | 1995 | |
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| 4,484,987 Method and membrane applicable to implantable sensor | 242 | 1983 | |
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| 4,650,547 Method and membrane applicable to implantable sensor | 253 | 1985 | |
| 4,703,756 Complete glucose monitoring system with an implantable, telemetered sensor module | 556 | 1986 | |
| 4,781,798 Transparent multi-oxygen sensor array and method of using same | 306 | 1987 | |
| 4,890,620 Two-dimensional diffusion glucose substrate sensing electrode | 350 | 1988 | |
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| 5,096,836 Diagnostic test carrier | 133 | 1990 | |
| 5,310,885 Process for immobilizing a protein containing substance on a solid phase | 109 | 1992 | |
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| 4,721,601 Molecule-based microelectronic devices | 178 | 1984 | |
| 4,717,673 Microelectrochemical devices | 153 | 1985 | |
| 4,936,956 Microelectrochemical devices based on inorganic redox active material and method for sensing | 120 | 1987 | |
| 5,034,192 Molecule-based microelectronic devices | 162 | 1989 | |
| 5,109,850 Automatic blood monitoring for medication delivery method and apparatus | 238 | 1991 | |
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| 4,427,770 High glucose-determining analytical element | 145 | 1982 | |
| 4,560,534 Polymer catalyst transducers | 154 | 1983 | |
| 4,714,874 Test strip identification and instrument calibration | 136 | 1985 | |
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| 5,378,628 Sensor for measuring the amount of a component in solution | 269 | 1992 | |
| 5,393,903 Mono, bis or tris(substituted 2,2'-bipyridine) iron, ruthenium, osmium or vanadium complexes and their methods of preparation | 225 | 1992 | |
| 5,395,504 Electrochemical measuring system with multizone sensors | 286 | 1994 | |
| 5,502,396 Measuring device with connection for a removable sensor | 235 | 1994 | |
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| 4,461,691 Organic conductive films for semiconductor electrodes | 162 | 1983 | |
| 5,082,550 Enzyme electrochemical sensor electrode and method of making it | 223 | 1989 | |
| 5,208,154 Reversibly immobilized biological materials in monolayer films on electrodes | 144 | 1991 | |
| 5,227,042 Catalyzed enzyme electrodes | 123 | 1992 | |
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| 5,582,184 Interstitial fluid collection and constituent measurement | 492 | 1994 | |
| 5,746,217 Interstitial fluid collection and constituent measurement | 296 | 1995 | |
| 5,682,233 Interstitial fluid sampler | 295 | 1996 | |
| 5,820,570 Interstitial fluid collection and constituent measurement | 213 | 1997 | |
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| 5,391,250 Method of fabricating thin film sensors | 456 | 1994 | |
| 5,569,186 Closed loop infusion pump system with removable glucose sensor | 511 | 1994 | |
| 5,568,806 Transcutaneous sensor insertion set | 374 | 1995 | |
| 5,586,553 Transcutaneous sensor insertion set | 450 | 1995 | |
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| 4,938,860 Electrode for electrochemical sensors | 212 | 1985 | |
| 5,202,261 Conductive sensors and their use in diagnostic assays | 221 | 1991 | |
| 5,250,439 Use of conductive sensors in diagnostic assays | 239 | 1992 | |
| 5,410,474 Buttonless memory system for an electronic measurement device | 152 | 1993 | |
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| 4,911,794 Measuring with zero volume cell | 261 | 1987 | |
| 4,942,127 Polyredox couples in analyte determinations | 118 | 1988 | |
| 5,501,956 Polyredox couples in analyte determinations | 107 | 1994 | |
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| 4,366,033 Method for determining the concentration of sugar using an electrocatalytic sugar sensor | 170 | 1979 | |
| 4,477,314 Method for determining sugar concentration | 213 | 1983 | |
| 4,759,371 Implantable, calibrateable measuring instrument for a body substance and a calibrating method | 136 | 1987 | |
| 5,552,027 Working electrode for electrochemical enzymatic sensor systems | 104 | 1995 | |
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| 5,497,772 Glucose monitoring system | 527 | 1993 | |
| 5,660,163 Glucose sensor assembly | 427 | 1995 | |
| 5,791,344 Patient monitoring system | 499 | 1996 | |
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| 4,758,323 Assay systems using more than one enzyme | 240 | 1984 | |
| 4,840,893 Electrochemical assay for nucleic acids and nucleic acid probes | 292 | 1985 | |
| 4,830,959 Electrochemical enzymic assay procedures | 257 | 1986 | |
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| 5,494,562 Electrochemical sensors | 309 | 1994 | |
| 5,582,698 Sensor package | 142 | 1995 | |
| 5,770,028 Glucose and lactate sensors | 128 | 1996 | |
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| 4,927,516 Enzyme sensor | 289 | 1987 | |
| 4,968,400 Enzyme sensor | 122 | 1989 | |
| 5,133,856 Ion sensor | 141 | 1990 | |
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| 5,262,305 Interferant eliminating biosensors | 333 | 1991 | |
| 5,320,725 Electrode and method for the detection of hydrogen peroxide | 304 | 1992 | |
| 5,356,786 Interferant eliminating biosensor | 409 | 1993 | |
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| 4,919,767 Sensor and method for analyte determination | 139 | 1988 | |
| 5,437,973 Enzyme-electrode sensor | 107 | 1993 | |
| 5,531,878 Sensor devices | 338 | 1995 | |
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| 4,356,074 Substrate specific galactose oxidase enzyme electrodes | 162 | 1980 | |
| 4,404,066 Method for quantitatively determining a particular substrate catalyzed by a multisubstrate enzyme | 173 | 1982 | |
| 5,217,595 Electrochemical gas sensor | 137 | 1991 | |
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| 5,478,751 Self-venting immunodiagnositic devices and methods of performing assays | 109 | 1994 | |
| 5,520,787 Diagnostic flow cell device | 167 | 1995 | |
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| 5,262,035 Enzyme electrodes | 310 | 1989 | |
| 5,593,852 Subcutaneous glucose electrode | 495 | 1994 | |
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| 4,970,145 Immobilized enzyme electrodes | 255 | 1988 | |
| 5,846,744 Sensors based on polymer transformation | 151 | 1996 | |
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| 4,571,292 Apparatus for electrochemical measurements | 303 | 1982 | |
| 4,655,880 Apparatus and method for sensing species, substances and substrates using oxidase | 316 | 1983 | |
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| 5,101,814 System for monitoring and controlling blood glucose | 384 | 1989 | |
| 5,368,028 System for monitoring and controlling blood and tissue constituent levels | 221 | 1993 | |
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| 4,401,122 Cutaneous methods of measuring body substances | 210 | 1979 | |
| 4,680,268 Implantable gas-containing biosensor and method for measuring an analyte such as glucose | 300 | 1985 | |
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| 4,757,022 Biological fluid measuring device | 486 | 1987 | |
| 4,994,167 Biological fluid measuring device | 315 | 1988 | |
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| 5,411,647 Techniques to improve the performance of electrochemical sensors | 401 | 1994 | |
| 5,695,623 Glucose measuring device | 318 | 1994 | |
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| 6,143,164 Small volume in vitro analyte sensor | 474 | 1998 | |
| 6,120,676 Method of using a small volume in vitro analyte sensor | 535 | 1999 | |
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| 4,407,959 Blood sugar analyzing apparatus | 157 | 1981 | |
| 4,483,924 System for controlling a printer in a blood sugar analyzer | 115 | 1981 | |
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| 5,200,051 Wholly microfabricated biosensors and process for the manufacture and use thereof | 508 | 1989 | |
| 5,837,454 Process for the manufacture of wholly microfabricated biosensors | 191 | 1995 | |
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| 4,318,784 Enzymatic processes | 117 | 1980 | |
| 4,655,885 Surface-modified electrode and its use in a bioelectrochemical process | 147 | 1986 | |
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| 5,082,786 Glucose sensor with gel-immobilized glucose oxidase and gluconolactonase | 147 | 1988 | |
| 5,384,028 Biosensor with a data memory | 245 | 1993 | |
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| 5,352,348 Method of using enzyme electrode | 186 | 1992 | |
| 6,287,451 Disposable sensor and method of making | 114 | 1999 | |
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| 4,543,955 System for controlling body implantable action device | 243 | 1983 | |
| 4,815,469 Implantable blood oxygen sensor and method of use | 262 | 1988 | |
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| 5,288,636 Enzyme electrode system | 367 | 1990 | |
| 5,508,171 Assay method with enzyme electrode system | 348 | 1994 | |
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| 4,871,440 Biosensor | 264 | 1988 | |
| 4,950,378 Biosensor | 156 | 1988 | |
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| 2002/0191,558 Distributed soft handoff among IP-based base stations | 2001 | ||
| 2002/0191,558 Distributed soft handoff among IP-based base stations | 2001 | ||
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| 4,813,424 Long-life membrane electrode for non-ionic species | 178 | 1987 | |
| 4,986,271 Vivo refillable glucose sensor | 235 | 1989 | |
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| 6,071,391 Enzyme electrode structure | 298 | 1997 | |
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| 5,514,253 Method of measuring gas concentrations and microfabricated sensing device for practicing same | 136 | 1994 | |
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| 4,619,754 Chemically modified electrodes and their uses | 230 | 1983 | |
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| 4,524,114 Bifunctional air electrode | 147 | 1983 | |
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| 4,935,345 Implantable microelectronic biochemical sensor incorporating thin film thermopile | 229 | 1987 | |
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| 4,206,755 Method and apparatus for the control and regulation of glycemia | 189 | 1978 | |
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| 5,130,009 Sensor device | 111 | 1990 | |
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| 4,526,661 Electrochemical hydrogenation of nicotinamide adenine dinucleotide | 142 | 1983 | |
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| 4,974,929 Fiber optical probe connector for physiologic measurement devices | 253 | 1990 | |
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| 4,784,736 Functional, photochemically active, and chemically asymmetric membranes by interfacial polymerization of derivatized multifunctional prepolymers | 153 | 1986 | |
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| 6,033,866 Highly sensitive amperometric bi-mediator-based glucose biosensor | 209 | 1997 | |
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| 4,534,356 Solid state transcutaneous blood gas sensors | 217 | 1982 | |
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| 4,552,840 Enzyme electrode and method for dextran analysis | 166 | 1982 | |
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| 5,599,479 Ferroelectric chiral smectic liquid crystal composition and liquid crystal device using same | 7 | 1989 | |
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| 4,679,562 Glucose sensor | 196 | 1986 | |
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| 5,094,951 Production of glucose oxidase in recombinant systems | 131 | 1989 | |
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| 5,198,367 Homogeneous amperometric immunoassay | 144 | 1989 | |
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| 4,271,119 Capillary transport device having connected transport zones | 123 | 1980 | |
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| 5,525,511 Electrochemical biosensor stability | 194 | 1993 | |
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| 4,365,637 Perspiration indicating alarm for diabetics | 147 | 1980 | |
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| 5,387,327 Implantable non-enzymatic electrochemical glucose sensor | 183 | 1992 | |
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| 4,450,842 Solid state reference electrode | 145 | 1981 | |
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| 5,617,851 Ultrasonic transdermal system for withdrawing fluid from an organism and determining the concentration of a substance in the fluid | 229 | 1995 | |
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| 4,436,094 Monitor for continuous in vivo measurement of glucose concentration | 285 | 1982 | |
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| 4,759,828 Glucose electrode and method of determining glucose | 318 | 1987 | |
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| 5,670,031 Electrochemical sensor | 199 | 1995 | |
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| 5,842,983 Biosensor | 111 | 1996 | |
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| 4,795,707 Electrochemical sensor having three layer membrane containing immobilized enzymes | 146 | 1985 | |
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| 4,522,690 Electrochemical sensing of carbon monoxide | 153 | 1983 | |
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| 4,923,586 Enzyme electrode unit | 136 | 1989 | |
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| 5,326,449 Composite membrane | 146 | 1993 | |
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| 4,832,797 Enzyme electrode and membrane | 151 | 1986 | |
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| 4,935,105 Methods of operating enzyme electrode sensors | 181 | 1989 | |
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| 4,919,141 Implantable electrochemical sensor | 283 | 1988 | |
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| 5,141,868 Device for use in chemical test procedures | 443 | 1989 | |
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| 5,708,247 Disposable glucose test strips, and methods and compositions for making same | 378 | 1996 | |
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| 4,340,458 Glucose sensor | 163 | 1980 | |
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| 4,726,378 Adjustable magnetic supercutaneous device and transcutaneous coupling apparatus | 143 | 1986 | |
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| 4,637,403 Glucose medical monitoring system | 501 | 1985 | |
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| 4,945,045 Electrochemical methods of assay | 272 | 1988 | |
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| 5,120,421 Electrochemical sensor/detector system and method | 253 | 1990 | |
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| 5,711,861 Device for monitoring changes in analyte concentration | 375 | 1995 | |
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| 5,526,120 Test strip with an asymmetrical end insuring correct insertion for measuring | 268 | 1994 | |
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| 5,293,546 Oxide coated metal grid electrode structure in display devices | 158 | 1991 | |
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| 5,078,854 Polarographic chemical sensor with external reference electrode | 111 | 1990 | |
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| 5,741,211 System and method for continuous monitoring of diabetes-related blood constituents | 242 | 1995 | |
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| 4,654,197 Cuvette for sampling and analysis | 240 | 1984 | |
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| 5,390,671 Transcutaneous sensor insertion set | 477 | 1994 | |
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| 4,764,416 Electric element circuit using oxidation-reduction substances | 142 | 1987 | |
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| 5,380,422 Micro-electrode and method for preparing it | 107 | 1992 | |
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| 5,096,560 Electrode for electrochemical detectors | 101 | 1990 | |
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| 5,364,797 Sensor device containing mesoporous crystalline material | 188 | 1993 | |
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| 5,372,133 Implantable biomedical sensor device, suitable in particular for measuring the concentration of glucose | 341 | 1993 | |
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| 5,422,246 Electrode having a polymer coating with a redox enzyme bound thereto, the polymer coating being formed on the walls of pores extending through a porous membrane | 127 | 1993 | |
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| 5,192,416 Method and apparatus for batch injection analysis | 136 | 1991 | |
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| 5,037,527 Reference electrode and a measuring apparatus using the same | 105 | 1988 | |
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| 5,680,858 Method and apparatus for in vivo determination of the concentration in a body fluid of metabolically significant substances | 232 | 1995 | |
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| 5,741,688 Alkaline glucose oxidase obtained from cladosporium oxysporum | 100 | 1995 | |
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| 4,444,892 Analytical device having semiconductive organic polymeric element associated with analyte-binding substance | 177 | 1982 | |
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| 5,711,862 Portable biochemical measurement device using an enzyme sensor | 131 | 1996 | |
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| 4,894,137 Enzyme electrode | 168 | 1987 | |
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| 5,126,247 Method, system and devices for the assay and detection of biochemical molecules | 141 | 1988 | |
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| 4,682,602 Probe for medical application | 169 | 1985 | |
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| 5,264,103 Biosensor and a method for measuring a concentration of a substrate in a sample | 397 | 1992 | |
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| 4,750,496 Method and apparatus for measuring blood glucose concentration | 212 | 1987 | |
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| 5,089,112 Electrochemical biosensor based on immobilized enzymes and redox polymers | 332 | 1990 | |
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| 4,684,537 Process for the sensitization of an oxidation/reduction photocatalyst, and photocatalyst thus obtained | 161 | 1985 | |
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| 4,375,399 Molecule selective sensor for industrial use and procedure for its preparation | 135 | 1980 | |
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| 5,174,291 Process for using a measuring cell assembly for glucose determination | 195 | 1990 | |
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| 5,804,048 Electrode assembly for assaying glucose | 179 | 1996 | |
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| 4,848,351 Medical electrode assembly | 134 | 1988 | |
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| 5,140,393 Sensor device | 136 | 1990 | |
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| 4,820,399 Enzyme electrodes | 294 | 1985 | |
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| 4,573,994 Refillable medication infusion apparatus | 308 | 1981 | |
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| 5,278,079 Sealing device and method for inhibition of flow in capillary measuring devices | 124 | 1992 | |
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| 5,161,532 Integral interstitial fluid sensor | 185 | 1990 | |
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| 4,854,153 Automatic calibration apparatus for a partial gas pressure measuring sensor | 28 | 1987 | |
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| 6,153,069 Apparatus for amperometric Diagnostic analysis | 228 | 1995 | |
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| 4,897,162 Pulse voltammetry | 202 | 1988 | |
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| 5,580,527 Polymeric luminophores for sensing of oxygen | 126 | 1994 | |
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| 5,596,150 Capacitance probe for fluid flow and volume measurements | 135 | 1995 | |
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| 4,420,564 Blood sugar analyzer having fixed enzyme membrane sensor | 254 | 1981 | |
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| 5,206,145 Method of measuring the concentration of a substance in a sample solution | 108 | 1991 | |
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| 4,240,889 Enzyme electrode provided with immobilized enzyme membrane | 271 | 1979 | |
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| 5,165,407 Implantable glucose sensor | 448 | 1991 | |
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| 4,805,624 Low-potential electrochemical redox sensors | 215 | 1987 | |
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| 4,440,175 Membrane electrode for non-ionic species | 162 | 1981 | |
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| 4,581,336 Surface-modified electrodes | 163 | 1983 | |
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| 5,556,524 Electron-conducting molecular preparations | 133 | 1995 | |
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| 5,271,815 Method for measuring glucose | 156 | 1991 | |
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| 4,240,438 Method for monitoring blood glucose levels and elements | 208 | 1978 | |
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| 5,286,364 Surface-modified electochemical biosensor | 272 | 1991 | |
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| 4,384,586 Method and apparatus for pH recording | 140 | 1980 | |
| 4,431,004 Implantable glucose sensor | 421 | 1981 | |
| 4,469,110 Device for causing a pinprick to obtain and to test a drop of blood | 329 | 1982 | |
| 4,538,616 Blood sugar level sensing and monitoring transducer | 266 | 1983 | |
| 4,633,878 Device for the automatic insulin or glucose infusion in diabetic subjects, based on the continuous monitoring of the patient's glucose, obtained without blood withdrawal | 225 | 1984 | |
| 4,595,011 Transdermal dosimeter and method of use | 202 | 1984 | |
| 4,685,463 Device for continuous in vivo measurement of blood glucose concentrations | 258 | 1986 | |
| 5,070,535 Transcutaneous power and signal transmission system and methods for increased signal transmission efficiency | 162 | 1987 | |
| 4,822,337 Insulin delivery method and apparatus | 153 | 1987 | |
| 4,871,351 Implantable medication infusion system | 421 | 1987 | |
| 4,776,944 Chemical selective sensors utilizing admittance modulated membranes | 216 | 1987 | |
| 4,909,908 Electrochemical cncentration detector method | 166 | 1988 | |
| 4,953,552 Blood glucose monitoring system | 598 | 1989 | |
| 5,205,920 Enzyme sensor and method of manufacturing the same | 227 | 1990 | |
| 5,337,747 Implantable device for estimating glucose levels | 290 | 1993 | |
| 5,830,341 Electrodes and metallo isoindole ringed compounds | 115 | 1996 | |
Patent Citation Ranking
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Dec 15, 2015 |
| Fee | Large entity fee | small entity fee | micro entity fee |
|---|---|---|---|
| Surcharge - 11.5 year - Late payment within 6 months | $160.00 | $80.00 | $40.00 |
| Surcharge after expiration - Late payment is unavoidable | $700.00 | $350.00 | $175.00 |
| Surcharge after expiration - Late payment is unintentional | $1,640.00 | $820.00 | $410.00 |