Vaccine against lipopolysaccharide core

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United States of America Patent

PATENT NO 6749831
SERIAL NO

09423546

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Abstract

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Compare core LPS (lacking O-polysaccharide side chains) from Gram-negative bacteria are incorporated into a vaccine typically in liposomes. The complete core of E. coli K 12 is particularly useful. Upon administration to a mammal the vaccine stimulates synthesis of antibodies which are cross-protective against smooth and rough forms of LPS from at least two different Gram-negative bacterial strains having different core structures.

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Patent Owner(s)

Patent OwnerAddress
MEDICAL DEFENSE TECHNOLOGY LLCNEW YORK NY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barclay, George Robin Midlothian, GB 3 16
Bennett-Guerrero, Elliott New York, NY 13 125
McIntosh, Thomas James Durham, NC 2 8
Poxton, Ian Raymond Edinburgh, GB 3 16
Snyder, David Scott Durham, NC 8 10

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