Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 6749868
SERIAL NO

09316642

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

In accordance with the present invention, there are provided compositions and methods useful for the in vivo delivery of substantially water insoluble pharmacologically active agents (such as the anticancer drug paclitaxel) in which the pharmacologically active agent is delivered in the form of suspended particles coated with protein (which acts as a stabilizing agent). In particular, protein and pharmacologically active agent in a biocompatible dispersing medium are subjected to high shear, in the absence of any conventional surfactants, and also in the absence of any polymeric core material for the particles. The procedure yields particles with a diameter of less than about 1 micron. The use of specific composition and preparation conditions (e.g., addition of a polar solvent to the organic phase), and careful election of the proper organic phase and phase fraction, enables the reproducible production of unusually small nanoparticles of less than 200 nm diameter, which can be sterile-filtered. The particulate system produced according to the invention can be converted into a redispersible dry powder comprising nanoparticles of water-insoluble drug coated with a protein, and free protein to which molecules of the pharmacological agent are bound. This results in a unique delivery system, in which part of the pharmacologically active agent is readily bioavailable (in the form of molecules bound to the protein), and part of the agent is present within particles without any polymeric matrix therein.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
ABRAXIS BIOSCIENCE, LLCLOS ANGELES, CA71

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Desai, Neil P Los Angeles, CA 198 8830
Louie, Leslie Montebello, CA 5 362
Magdassi, Shlomo Jerusalem, IL 58 967
Soon-Shiong, Patrick Los Angeles, CA 220 5741
Tao, Chunlin Beverly Hills, CA 57 869
Yang, Andrew Rosemead, CA 37 1114
Yao, Zhiwen Culver City, CA 4 355

Cited Art Landscape

Patent Info (Count) # Cites Year
 
GENSIA SICOR PHARMACEUTICALS, INC. (1)
6469069 Propofol composition containing sulfite 25 2000
 
NOVARTIS CORPORATION (1)
5744460 Combination for treatment of proliferative diseases 39 1996
 
AMERICAN HOME PRODUCTS CORPORATION (1)
4344934 Therapeutic compositions with enhanced bioavailability 51 1980
 
BRISTOL-MYERS SQUIBB COMPANY (1)
5504102 Stabilized pharmaceutical composition and stabilizing solvent 59 1995
 
GENSIA SICOR INC. (1)
6147122 Propofol composition containing sulfite 27 1999
 
TEKMIRA PHARMACEUTICALS CORPORATION (1)
5543152 Sphingosomes for enhanced drug delivery 108 1994
 
VETERINARY RESEARCH ASSOCIATES, INC. (1)
5962536 Injectable propofol formulations 21 1998
 
CEPHALON LIMITED (1)
5683715 Taxane-containing phosphatidylcholine liposomes 33 1995
 
GEORGETOWN UNIVERSITY (1)
5648090 Liposome encapsulated toxol and a method of using the same 25 1995
 
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (1)
5565478 Combination therapy using signal transduction inhibitors with paclitaxel and other taxane analogs 49 1994
 
Research Triangle Pharmaceuticals (1)
5637625 Propofol microdroplet formulations 49 1996
 
The Scripps Research Institute (1)
5731334 Method for treating cancer using taxoid onium salt prodrugs 7 1995
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
5626862 Controlled local delivery of chemotherapeutic agents for treating solid tumors 247 1994
 
Westy AG (1)
6326406 Clear, injectable formulation of an anesthetic compound 23 2000
 
Hospira, Inc. (1)
6140373 Propofol composition 25 1998
 
BAXTER INTERNATIONAL INC. (1)
6100302 Propofol formulation with enhanced microbial characteristics 29 1999
 
PG-TXL Company, L.P. (1)
5977163 Water soluble paclitaxel prodrugs 249 1997
 
ELAN PHARMA INTERNATIONAL LIMITED (1)
5399363 Surface modified anticancer nanoparticles 272 1992
 
POWERVERDE, INC. (1)
6362234 Water-soluble prodrugs of propofol for treatment of migrane 27 2000
 
FAULDING PHARMACEUTICAL CO. (2)
6028108 Propofol composition comprising pentetate 30 1998
6177477 Propofol formulation containing TRIS 28 1999
 
ABRAXIS BIOSCIENCE, LLC (5)
5439686 Methods for in vivo delivery of substantially water insoluble pharmacologically active agents and compositions useful therefor 226 1993
5498421 Composition useful for in vivo delivery of biologics and methods employing same 299 1994
* 5916596 Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof 184 1996
6096331 Methods and compositions useful for administration of chemotherapeutic agents 144 1997
* 6537579 Compositions and methods for administration of pharmacologically active compounds 131 2000
 
AMPHASTAR PHARMACEUTICALS, INC. (1)
6399087 Propofol formulation with enhanced microbial inhibition 23 2000
 
IVY ANIMAL HEALTH, INC. (1)
6150423 Propofol-based anesthetic and method of making same 27 1998
 
ZENECA LIMITED (4)
5714520 Propofol compostion containing edetate 54 1995
5731355 Pharmaceutical compositions of propofol and edetate 58 1997
5731356 Pharmaceutical compositions of propofol and edetate 35 1997
5908869 Propofol compositions containing edetate 31 1998
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
* 6995145 Methods and compositions for modulating drug activity through telomere damage 6 2000
* 8449919 Composition and method for preparing alginate nanocapsules 0 2006
 
INTERHEALTH NUTRACEUTICALS, INC. (2)
8748499 Collagen dispersion and method of producing same 0 2010
* 2010/0303,898 COLLAGEN DISPERSION AND METHOD OF PRODUCING SAME 1 2010
 
NITTO DENKO CORPORATION (7)
* 2007/0128,118 POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS 45 2006
* 2008/0181,852 Multi-functional Drug Carriers 5 2008
* 2008/0253,969 MULTI-FUNCTIONAL POLYGLUTAMATE DRUG CARRIERS 7 2008
8197828 Compositions that include a hydrophobic compound and a polyamino acid conjugate 0 2008
* 2008/0279,782 POLYMERS CONJUGATED WITH PLATINUM DRUGS 5 2008
* 2009/0226,393 POLYMER PACLITAXEL CONJUGATES AND METHODS FOR TREATING CANCER 5 2009
8329199 Compositions that include a hydrophobic compound and a polyamino acid conjugate 0 2012
 
SALPIETRA, JOHN M. "PETE",ROCHESTER HILLS,MI, SALPIETRA THOMAS G,"SALPIETRA, THOMAS G. (2)
* 8273560 Coated substrates and methods of preparing the same 0 2011
* 2012/0028,328 COATED SUBSTRATES AND METHODS OF PREPARING THE SAME 0 2011
 
TONIX PHARMACEUTICALS (1)
* 2011/0124,656 Methods and Compositions for Treating Symptoms Associated with Post-Traumatic Stress Disorder using Cyclobenzaprine 2 2010
 
SAMSUNG ELECTRONICS CO., LTD. (1)
* 9457082 Liposome including complex of hydrophobic active ingredient and polypeptide and use of the liposome 0 2014
 
Nanjing Effect Pharm Drug Development Corporation (2)
* 9066870 Methods for drug delivery comprising unfolding and folding proteins and peptide nanoparticles 0 2010
* 2011/0059,181 METHODS FOR DRUG DELIVERY COMPRISING UNFOLDING AND FOLDING PROTEINS AND PEPTIDE NANOPARTICLES 8 2010
 
UNIVERSITY OF NORTH TEXAS (2)
8048450 Aqueous dispersion of hydrogel nanoparticles with inverse thermoreversible gelation 0 2004
* 2007/0116,765 Aqueous dispersion of hydrogel nanoparticles with inverse thermoreversible gelation 4 2004
 
LUMINUS BIOSCIENCES, INC. (2)
8728527 Solid nanoparticle formulation of water insoluble pharmaceutical substances with reduced ostwald ripening 37 2007
* 2009/0238,878 Solid Nanoparticle Formulation of Water Insoluble Pharmaceutical Substances With Reduced Ostwald Ripening 7 2007
 
MEDTRONIC, INC. (1)
* 2006/0093,639 Method and device for destroying body tissue 3 2004
 
MASSACHUSETTS INSTITUTE OF TECHNOLOGY (1)
* 2009/0074,828 POLY(AMINO ACID) TARGETING MOIETIES 77 2008
 
Minu, LLC (1)
* 2005/0181,018 Ocular drug delivery 39 2005
 
PEYMAN, GHOLAM A. (5)
7722581 Crystalline lens drug delivery 9 2005
* 2006/0225,745 Crystalline lens drug delivery 0 2005
* 2006/0229,585 DRUG DELIVERY TO THE CRYSTALLINE LENS AND OTHER OCULAR STRUCTURES 2 2006
7458953 Ocular drainage device 32 2006
* 2007/0293,872 Ocular Drainage Device 42 2006
 
BEIJING HONGYIYAO SCIENCE & TECHNOLOGY DEVELOPMENT CO. LTD. (1)
* 2008/0020,052 Vascular Embolus Of Paclitaxel-Sodium Alginate Microsphere And Its Preparation 2 2005
 
CELGENE CORPORATION (2)
9125884 Methods for treating cancers using oral formulations of cytidine analogs 0 2012
9693987 Methods for treating cancers using oral formulations of cytidine analogs 0 2015
 
ELAN PHARMA INTERNATIONAL LIMITED (5)
* 2003/0054,042 Stabilization of chemical compounds using nanoparticulate formulations 29 2001
* 2004/0033,267 Nanoparticulate compositions of angiogenesis inhibitors 20 2003
* 2006/0210,638 Injectable compositions of nanoparticulate immunosuppressive compounds 45 2006
* 2006/0292,214 Nanoparticulate acetaminophen formulations 24 2006
* 2008/0226,732 NANOPARTICULATE COMPOSITIONS OF ANGIOGENESIS INHIBITORS 1 2007
 
BIOMED REALTY, L.P. (6)
7964196 Self-assembling nanoparticle drug delivery system 7 2005
* 2006/0292,174 Self-assembling nanoparticle drug delivery system 13 2005
8067011 Compositions and methods for treating B-cell malignancies 2 2007
* 2007/0269,370 Compositions and methods for treating B-cell malignancies 6 2007
9017695 Chimeric therapeutics, compositions, and methods for using same 0 2011
8865188 Methods and compositions for controlling assembly of viral proteins 0 2012
 
ALKERMES PHARMA IRELAND LIMITED (1)
* 2009/0004,277 Nanoparticle dispersion containing lactam compound 3 2005
 
AMERICAN BIOSCIENCE, INC. (1)
8846771 Compositions and methods of delivery of pharmacological agents 17 2012
 
ACADEMIA SINICA (1)
9764005 Suppression of cancer metastasis 0 2015
 
Fresenius Kabi USA, LLC (3)
8889346 Propofol formulations with non-reactive container closures 0 2013
9072655 Propofol formulations with non-reactive container closures 0 2014
9072656 Propofol formulations with non-reactive container closures 0 2014
 
ASTRAZENECA AB (4)
9402847 Combinations comprising (S)-4-amino-N-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide 0 2012
9487525 Crystalline forms of (s)-4-amino-n-(1-(4-chlorophenyl)-3-hydroxypropyl)-1-(7h-pyrrolo[2,3-d]pyrimidin-4-yl) piperidine-4-carboxamide 0 2013
9763950 Combination treatment 0 2014
9737540 Combination treatment of cancer 0 2016
 
Liquidia Technologies, Inc. (1)
* 2010/0055,459 Nanoparticles Having Functional Additives for Self and Directed Assembly and Methods of Fabricating Same 4 2007
 
TONIX PHARMA HOLDINGS LIMITED (2)
9636408 Eutectic formulations of cyclobenzaprine hydrochloride and amitriptyline hydrochloride 0 2014
9474728 Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine 1 2014
 
Mercator Medsystems, Inc. (1)
9061014 Intravascular delivery of nanoparticle compositions and uses thereof 11 2012
 
SYNTA PHARMACEUTICALS CORP. (16)
7763658 Treatment for cancers 10 2004
* 2004/0225,016 Treatment for cancers 18 2004
8017654 Combination cancer therapy with bis(thiohydrazide) amide compounds 1 2006
* 2009/0137,682 Combination cancer therapy with bis(thiohydrazide) amide compounds 20 2006
7939564 Combination with bis(thiohydrazide amides) for treating cancer 2 2007
7671092 Paclitaxel enhancer compounds 11 2008
7750042 Paclitaxel enhancer compound 10 2008
7652168 Synthesis of taxol enhancers 10 2008
* 2009/0005,594 Synthesis of taxol enhancers 14 2008
7795313 Bis(thio-hydrazide amide) salts for treatment of cancers 13 2009
* 2009/0281,172 BIS(THIO-HYDRAZIDE AMIDE) SALTS FOR TREATMENT OF CANCERS 3 2009
9107955 Paclitaxel enhancer compounds 0 2010
8048925 Bis(thio-hydrazide amide) salts for treatment of cancers 3 2010
* 2010/0324,143 BIS(THIO-HYDRAZIDE AMIDE) SALTS FOR TREATMENT OF CANCERS 11 2010
8461208 Bis(thio-hydrazide amide) salts for treatment of cancers 2 2011
9156783 Compounds for treating proliferative disorders 0 2013
 
CHEVRON PHILLIPS CHEMICAL COMPANY LP (2)
8809562 Use of metallocene compounds for cancer treatment 1 2012
9441000 Use of metallocene compounds for cancer treatment 0 2014
 
TEIKOKU PHARMA USA, INC. (4)
8569357 Taxane pro-emulsion formulations and methods making and using the same 0 2011
8940786 Non-aqueous taxane nanodispersion formulations and methods of using the same 2 2013
9308195 Non-aqueous taxane formulations and methods of using the same 1 2014
9763880 Non-aqueous taxane formulations and methods of using the same 0 2016
 
DUKE UNIVERSITY (2)
8013022 Stabilized products, process and devices for preparing same 2 2007
* 2007/0258,960 Stabilized products, process and devices for preparing same 4 2007
 
ONCBIOMUNE, INC. (2)
9333189 Taxane- and taxoid-protein compositions 0 2011
* 2011/0190,204 Taxane- and Taxoid-Protein Compositions 2 2011
 
CERULEAN PHARMA INC. (7)
8497365 Cyclodextrin-based polymers for therapeutics delivery 3 2011
8404662 Cyclodextrin-based polymers for therapeutics delivery 0 2012
8609081 Cyclodextrin-based polymers for therapeutics delivery 0 2013
8580242 Cyclodextrin-based polymers for therapeutics delivery 0 2013
8518388 Cyclodextrin-based polymers for therapeutics delivery 0 2013
8603454 Cyclodextrin-based polymers for therapeutics delivery 0 2013
9550860 Cyclodextrin-based polymers for therapeutics delivery 0 2013
 
ABRAXIS BIOSCIENCE, INC. (4)
* 2007/0122,465 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof 5 2006
* 2007/0117,862 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof 8 2006
* 2007/0191,473 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof 3 2006
* 2007/0122,468 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof 5 2006
 
CERULIEAN PHARMA INC. (1)
9610360 Polymer drug conjugates with tether groups for controlled drug delivery 0 2013
 
ABRAXIS BIOSCIENCE, LLC (60)
* 2003/0199,425 Compositions and methods for treatment of hyperplasia 35 2001
* 2005/0004,002 Compositions and methods of delivery of pharmacological agents 52 2003
8034375 Combinations and modes of administration of therapeutic agents and combination therapy 25 2006
* 2006/0263,434 Combinations and modes of administration of therapeutic agents and combination therapy 41 2006
8034765 Compositions and methods for preparation of poorly water soluble drugs with increased stability 54 2006
7771751 Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents 27 2006
* 2007/0117,744 Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents 28 2006
* 2007/0082,838 Compositions and methods for preparation of poorly water soluble drugs with increased stability 51 2006
8853260 Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof 19 2006
8137684 Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof 24 2006
* 2007/0092,563 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof 14 2006
* 2007/0093,547 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof 33 2006
8257733 Methods and compositions for treating proliferative diseases 24 2006
* 2007/0116,774 Methods and compositions for treating proliferative diseases 31 2006
7820788 Compositions and methods of delivery of pharmacological agents 36 2006
* 2010/0226,996 COMPOSITIONS AND METHODS OF DELIVERY OF PHARMACOLOGICAL AGENTS 8 2006
* 2007/0129,448 COMPOSITIONS AND METHODS OF DELIVERY OF PHARMACOLOGICAL AGENTS 32 2006
* 2007/0128,290 Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof 11 2006
* 7780984 Methods and compositions for treating proliferative diseases 21 2007
* 2008/0063,724 Methods and compostions for treating proliferative diseases 16 2007
* 2008/0280,987 Methods of inhibiting angiogenesis and treating angiogenesis-associated diseases 29 2007
9675578 Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane 0 2007
* 2010/0048,499 BREAST CANCER THERAPY BASED ON HORMONE RECEPTOR STATUS WITH NANOPARTICLES COMPRISING TAXANE 31 2007
8911786 Nanoparticle comprising rapamycin and albumin as anticancer agent 15 2008
* 2010/0183,728 NANOPARTICLE COMPRISING RAPAMYCIN AND ALBUMIN AS ANTICANCER AGENT 27 2008
* 2010/0166,869 METHODS AND COMPOSITIONS FOR TREATING PULMONARY HYPERTENSION 47 2008
8927019 Methods and compositions for treating recurrent cancer 14 2008
* 2010/0215,751 METHODS AND COMPOSITIONS FOR TREATING RECURRENT CANCER 27 2008
7758891 Combinations and modes of administration of therapeutic agents and combination therapy 25 2008
* 2009/0098,210 COMBINATIONS AND MODES OF ADMINISTRATION OF THERAPEUTIC AGENTS AND COMBINATION THERAPY 17 2008
7981445 Compositions and methods for preparation of poorly water soluble drugs with increased stability 24 2009
* 2009/0196,933 COMPOSITIONS AND METHODS FOR PREPARATION OF POORLY WATER SOLUBLE DRUGS WITH INCREASED STABILITY 23 2009
* 2009/0263,483 NANOPARTICLE FORMULATIONS AND USES THEREOF 31 2009
8735394 Combinations and modes of administration of therapeutic agents and combination therapy 18 2009
* 2009/0304,805 COMBINATIONS AND MODES OF ADMINISTRATION OF THERAPEUTIC AGENTS AND COMBINATION THERAPY 27 2009
* 2011/0052,708 METHODS AND FORMULATIONS FOR THE DELIVERY OF PHARMACOLOGICALLY ACTIVE AGENTS 26 2010
7923536 Compositions and methods of delivery of pharmacological agents 33 2010
* 2011/0118,342 COMPOSITIONS AND METHODS FOR PREPARATION OF POORLY WATER SOLUBLE DRUGS WITH INCREASED STABILITY 25 2010
* 2011/0151,012 COMPOSITIONS COMPRISING POORLY WATER SOLUBLE PHARMACEUTICAL AGENTS AND ANTIMICROBIAL AGENTS 25 2010
* 2011/0165,256 COMPOSITIONS AND METHODS FOR TREATMENT OF HYPERPLASIA 18 2010
8138229 Compositions and methods of delivery of pharmacological agents 31 2010
8314156 Compositions and methods of delivery of pharmacological agents 28 2011
9370494 Methods for treating hepatocellular carcinoma 0 2011
9393318 Methods of treating cancer 2 2011
9399071 Methods of treatment of pancreatic cancer 0 2011
8268348 Combinations and modes of administration of therapeutic agents and combination therapy 27 2011
9308180 Compositions and methods for preparation of poorly water soluble drugs with increased stability 0 2012
9101543 Combinations and modes of administration of therapeutic agents and combination therapy 12 2012
9585960 Use of polymeric excipients for lyophilization or freezing of particles 0 2012
9012518 Compositions and methods of delivery of pharmacological agents 13 2013
9012519 Compositions and methods of delivery of pharmacological agents 13 2013
9561288 Combinations and modes of administration of therapeutic agents and combination therapy 0 2013
8999396 Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane 14 2013
9597409 Methods of treating cancer 0 2013
9399072 Methods of treatment of pancreatic cancer 0 2013
9149455 Methods of treating melanoma 11 2013
9511046 Methods of treating pancreatic cancer 0 2013
9446003 Prion free nanoparticle compositions and methods of making thereof 0 2014
9671406 SPARC and methods of use thereof 0 2015
9724323 Breast cancer therapy based on hormone receptor status with nanoparticles comprising taxane 0 2015
* Cited By Examiner