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Abstract

The invention relates to nucleoside derivatives with photolabile protecting groups of general formula (I) ##STR1## wherein R.sup.1 is H, F, Cl, Br, I, or NO.sub.2 ; R.sup.2 is H or CN, provided that R.sup.1 and R.sup.2 are not simultaneously H; R.sup.3 is H, 1-4 C alkyl, or phenyl; R.sup.4 is H or a conventional functional group for the synthesis of oligonuleotides; R.sup.5 is H, OH, halogen or XR.sup.6, where X=O or S, and R.sup.6 is a conventional nucleotide protecting group; and B is adenine, cytosine, guanine, thymine, uracil, 2,6-diaminopurin-9-yl, hypoxanthin-9-yl, 5-methylcytosin-1-yl, 5-amino-4-imidazolcarboxamid-1-yl or 5-amino-4-imidazolcarboxamid-3-yl, where, if B is adenine, cytosine or guanine the primary amine functionality, optionally, carries a permanent protecting group. Furthermore, these derivatives may be used for the light-controlled synthesis of oligonucleotides on a DNA chip.

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First Claim