Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals
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United States of America Patent
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Jun 22, 2004
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N/A
app pub date -
Apr 10, 2000
filing date -
Jan 11, 1990
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Expired
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Abstract
The invention is directed to oligonucleotides and oligonucleosides functionalized to include lipophilic moieties and having improved biostability and altered biodistribution in mammals. In one embodiment, such lipophilic oligonucleotide conjugates are used in a method of targeting antisense oligonucleotides to hepatic tissues and thereby preferentially modulating gene expression in the liver and associated tissues of a mammal.
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