Prodrugs of CC-1065 analogs
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United States of America Patent
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Jun 29, 2004
Grant Date -
Oct 23, 2003
app pub date -
Apr 5, 2002
filing date -
Apr 5, 2002
priority date (Note) -
Expired
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Abstract
Prodrugs of analogs of the anti-tumor antibiotic CC-1065 having a cleavable protective group such as a piperazino carbamate, a 4-piperidino-piperidino carbamate or a phosphate, in which the protecting group confers enhanced water solubility and stability upon the prodrug, and in which the prodrug also has a moiety, such as a disulfide, that can conjugate to a cell binding reagent such as an antibody. The therapeutic use of such prodrug conjugates is also described; such prodrugs of cytotoxic agents have therapeutic use because they can deliver cytotoxic prodrugs to a specific cell population for enzymatic conversion to cytoxic drugs in a targeted fashion.
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