US Patent No: 6,759,029

Number of patents in Portfolio can not be more than 2000

Delivery of rizatriptan and zolmitriptan through an inhalation route

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ATTORNEY / AGENT: (SPONSORED)

Importance

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Abstract

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The present invention relates to the delivery of rizatriptan or zolmitriptan through an inhalation route. Specifically, it relates to aerosols containing rizatriptan or zolmitriptan that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of rizatriptan or zolmitriptan. In a method aspect of the present invention, either rizatriptan or zolmitriptan is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of rizatriptan or zolmitriptan, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering rizatriptan or zolmitriptan through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of rizatriptan or zolmitriptan; and, b) a device that forms a rizatriptan or zolmitriptan containing aerosol from the composition, for inhalation by the mammal.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ALEXZA PHARMACEUTICALS, INC.PALO ALTO, CA61

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hale, Ron L Woodside, CA 68 2498
Rabinowitz, Joshua D Mountain View, CA 142 7597
Solas, Dennis W San Francisco, CA 67 3542
Zaffaroni, Alejandro C Atherton, CA 107 6563

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
6,591,839 Filter material for reducing harmful substances in tobacco smoke 113 2001
 
ALEXZA PHARMACEUTICALS, INC. (1)
2003/0032,638 Delivery of benzodiazepines through an inhalation route 120 2002
 
SANSA CORPORATION (BARBADOS) INC. (1)
6,102,036 Breath activated inhaler 151 1998
 
VAPIR, INC. (1)
6,095,153 Vaporization of volatile materials 190 1998
 
ALLIANCE PHARMACEUTICAL CORP. (1)
* 6,041,777 Methods and apparatus for closed-circuit ventilation therapy 213 1995
 
Civitas Therapeutics, Inc. (1)
* 6,514,482 Pulmonary delivery in treating disorders of the central nervous system 147 2000
 
ARADIGM CORPORATION (7)
5,544,646 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 202 1994
5,957,124 Dynamic particle size control for aerosolized drug delivery 174 1995
5,694,919 Lockout device for controlled release of drug from patient-activated dispenser 195 1995
5,915,378 Creating an aerosolized formulation of insulin 144 1995
5,934,272 Device and method of creating aerosolized mist of respiratory drug 235 1995
5,960,792 Device for aerosolized delivery of peptide drugs 188 1995
5,735,263 Lockout device for controlled release of drug from patient-activated dispenser 199 1996
 
NOVARTIS PHARMA AG (1)
5,758,637 Liquid dispensing apparatus and methods 210 1996
 
R. J. REYNOLDS TOBACCO COMPANY (1)
5,388,574 Aerosol delivery article 178 1993
 
PFIZER INC. (1)
* 6,255,334 5HT 1 receptor agonists and metoclopramide for the treatment of migraine 99 1999
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
ALEXZA PHARMACEUTICALS, INC. (53)
* 7,766,013 Aerosol generating method and device 9 2001
7,942,147 Aerosol forming device for use in inhalation therapy 4 2002
7,537,009 Method of forming an aerosol for inhalation delivery 13 2002
7,458,374 Method and apparatus for vaporizing a compound 52 2002
8,003,080 Delivery of drug amines through an inhalation route 6 2003
* 2004/0009,128 Delivery of drug amines through an inhalation route 95 2003
7,913,688 Inhalation device for producing a drug aerosol 21 2003
8,288,372 Method for treating headache with loxapine 3 2003
7,402,777 Stable initiator compositions and igniters 22 2004
* 2004/0234,916 Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same 49 2004
7,540,286 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 17 2004
7,581,540 Aerosol drug delivery device incorporating percussively activated heat packages 16 2004
7,442,368 Delivery of stimulants through an inhalation route 15 2006
7,498,019 Delivery of compounds for the treatment of headache through an inhalation route 11 2006
7,449,172 Delivery of antiemetics through an inhalation route 14 2006
7,465,435 Delivery of beta-blockers through an inhalation route 12 2006
7,465,436 Delivery of compounds for the treatment of Parkinson's through an inhalation route 12 2006
7,485,285 Delivery of antidepressants through an inhalation route 12 2006
7,449,173 Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route 18 2006
7,465,437 Delivery of anti-migraine compounds through an inhalation route 12 2006
7,524,484 Delivery of diphenhydramine through an inhalation route 10 2006
7,507,398 Delivery of physiologically active compounds through an inhalation route 36 2006
* 7,449,174 Delivery of analgesics through an inhalation route 14 2006
* 7,449,175 Delivery of erectile dysfunction drugs through an inhalation route 15 2006
* 2006/0251,588 Delivery of erectile dysfunction drugs through an inhalation route 32 2006
7,601,337 Delivery of antipsychotics through an inhalation route 8 2006
7,488,469 Delivery of caffeine through an inhalation route 12 2006
* 2006/0280,692 Delivery of antipsychotics through an inhalation route 42 2006
* 2006/0257,329 Delivery of drug esters through an inhalation route 47 2006
7,510,702 Delivery of nonsteroidal antiinflammatory drugs through an inhalation route 11 2006
7,470,421 Delivery of diazepam through an inhalation route 15 2006
* 7,445,768 Delivery of sedative-hypnotics through an inhalation route 16 2006
7,491,047 Delivery of antihistamines through an inhalation route 12 2006
7,507,397 Delivery of muscle relaxants through an inhalation route 12 2006
7,468,179 Delivery of opioids through an inhalation route 30 2007
7,981,401 Diuretic aerosols and methods of making and using them 4 2007
* 2008/0299,048 MIXED DRUG AEROSOL COMPOSITIONS 12 2007
7,923,662 Stable initiator compositions and igniters 6 2008
7,988,952 Delivery of drug esters through an inhalation route 3 2008
8,235,037 Drug condensation aerosols and kits 3 2008
7,834,295 Printable igniters 5 2008
* 2010/0065,052 Heating Units 6 2008
7,987,846 Method and apparatus for vaporizing a compound 3 2008
8,173,107 Delivery of antipsychotics through an inhalation route 3 2009
8,074,644 Method of forming an aerosol for inhalation delivery 3 2009
8,333,197 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 2 2009
8,387,612 Self-contained heating unit and drug-supply unit employing same 2 2009
8,506,935 Respiratory drug condensation aerosols and methods of making and using them 0 2009
* 2010/0300,433 Substrates for Enhancing Purity or Yield of Compounds Forming a Condensation Aerosol 5 2010
9,308,208 Aerosol generating method and device 0 2010
9,211,382 Drug condensation aerosols and kits 0 2012
8,991,387 Self-contained heating unit and drug-supply unit employing same 0 2013
8,955,512 Method of forming an aerosol for inhalation delivery 0 2013
 
PHILIP MORRIS USA INC. (1)
* 7,743,766 Aerosol generating devices and methods for generating aerosols having controlled particle sizes 1 2005
 
CHRYSALIS TECHNOLOGIES INCORPORATED (1)
* 2005/0205,084 Aerosol generating devices and methods for generating aerosols having controlled particle sizes 9 2005
 
BASBAUM, ALLAN (1)
* 2008/0064,725 INTRATHECAL ADMINISTRATION OF TRIPTAN COMPOSITIONS TO TREAT NON-MIGRAINE PAIN 2 2007
* Cited By Examiner

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