Delivery of rizatriptan and zolmitriptan through an inhalation route

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 6759029
APP PUB NO 20030005925A1
SERIAL NO

10155621

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to the delivery of rizatriptan or zolmitriptan through an inhalation route. Specifically, it relates to aerosols containing rizatriptan or zolmitriptan that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of rizatriptan or zolmitriptan. In a method aspect of the present invention, either rizatriptan or zolmitriptan is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of rizatriptan or zolmitriptan, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering rizatriptan or zolmitriptan through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of rizatriptan or zolmitriptan; and, b) a device that forms a rizatriptan or zolmitriptan containing aerosol from the composition, for inhalation by the mammal.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ALEXZA PHARMACEUTICALS, INC.PALO ALTO, CA64

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hale, Ron L Woodside, CA 69 2741
Rabinowitz, Joshua D Mountain View, CA 146 8103
Solas, Dennis W San Francisco, CA 67 3913
Zaffaroni, Alejandro C Atherton, CA 108 6937

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
6591839 Filter material for reducing harmful substances in tobacco smoke 116 2001
 
ALEXZA PHARMACEUTICALS, INC. (1)
2003/0032,638 Delivery of benzodiazepines through an inhalation route 123 2002
 
VAPIR, INC. (1)
6095153 Vaporization of volatile materials 212 1998
 
ALLIANCE PHARMACEUTICAL CORP. (1)
* 6041777 Methods and apparatus for closed-circuit ventilation therapy 234 1995
 
CIVITAS THERAPEUTICS, INC. (1)
* 6514482 Pulmonary delivery in treating disorders of the central nervous system 165 2000
 
SANSA CORPORATION (BARBADOS) INC. (1)
6102036 Breath activated inhaler 159 1998
 
ARADIGM CORPORATION (7)
5544646 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 210 1994
5957124 Dynamic particle size control for aerosolized drug delivery 181 1995
5694919 Lockout device for controlled release of drug from patient-activated dispenser 204 1995
5915378 Creating an aerosolized formulation of insulin 149 1995
5934272 Device and method of creating aerosolized mist of respiratory drug 265 1995
5960792 Device for aerosolized delivery of peptide drugs 194 1995
5735263 Lockout device for controlled release of drug from patient-activated dispenser 209 1996
 
NOVARTIS PHARMA AG (1)
5758637 Liquid dispensing apparatus and methods 219 1996
 
R. J. REYNOLDS TOBACCO COMPANY (1)
5388574 Aerosol delivery article 199 1993
 
PFIZER INC. (1)
* 6255334 5HT 1 receptor agonists and metoclopramide for the treatment of migraine 102 1999
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
ALEXZA PHARMACEUTICALS, INC. (56)
* 7766013 Aerosol generating method and device 12 2001
7942147 Aerosol forming device for use in inhalation therapy 9 2002
7537009 Method of forming an aerosol for inhalation delivery 17 2002
7458374 Method and apparatus for vaporizing a compound 64 2002
8003080 Delivery of drug amines through an inhalation route 12 2003
* 2004/0009,128 Delivery of drug amines through an inhalation route 98 2003
7913688 Inhalation device for producing a drug aerosol 44 2003
8288372 Method for treating headache with loxapine 7 2003
7402777 Stable initiator compositions and igniters 25 2004
* 2004/0234,916 Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same 52 2004
7540286 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 22 2004
7581540 Aerosol drug delivery device incorporating percussively activated heat packages 20 2004
7442368 Delivery of stimulants through an inhalation route 18 2006
7498019 Delivery of compounds for the treatment of headache through an inhalation route 14 2006
7449172 Delivery of antiemetics through an inhalation route 17 2006
7465435 Delivery of beta-blockers through an inhalation route 15 2006
7465436 Delivery of compounds for the treatment of Parkinson's through an inhalation route 15 2006
7485285 Delivery of antidepressants through an inhalation route 15 2006
7449173 Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route 21 2006
7465437 Delivery of anti-migraine compounds through an inhalation route 15 2006
7524484 Delivery of diphenhydramine through an inhalation route 13 2006
7507398 Delivery of physiologically active compounds through an inhalation route 45 2006
* 7449174 Delivery of analgesics through an inhalation route 17 2006
* 7449175 Delivery of erectile dysfunction drugs through an inhalation route 18 2006
* 2006/0251,588 Delivery of erectile dysfunction drugs through an inhalation route 32 2006
7601337 Delivery of antipsychotics through an inhalation route 11 2006
7488469 Delivery of caffeine through an inhalation route 15 2006
* 2006/0280,692 Delivery of antipsychotics through an inhalation route 42 2006
* 2006/0257,329 Delivery of drug esters through an inhalation route 50 2006
7510702 Delivery of nonsteroidal antiinflammatory drugs through an inhalation route 14 2006
7470421 Delivery of diazepam through an inhalation route 18 2006
* 7445768 Delivery of sedative-hypnotics through an inhalation route 19 2006
7491047 Delivery of antihistamines through an inhalation route 15 2006
7507397 Delivery of muscle relaxants through an inhalation route 15 2006
7468179 Delivery of opioids through an inhalation route 34 2007
7981401 Diuretic aerosols and methods of making and using them 7 2007
* 2008/0299,048 MIXED DRUG AEROSOL COMPOSITIONS 15 2007
7923662 Stable initiator compositions and igniters 9 2008
7988952 Delivery of drug esters through an inhalation route 6 2008
8235037 Drug condensation aerosols and kits 6 2008
7834295 Printable igniters 8 2008
* 2010/0065,052 Heating Units 9 2008
7987846 Method and apparatus for vaporizing a compound 6 2008
8173107 Delivery of antipsychotics through an inhalation route 6 2009
8074644 Method of forming an aerosol for inhalation delivery 8 2009
8333197 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 6 2009
8387612 Self-contained heating unit and drug-supply unit employing same 9 2009
8506935 Respiratory drug condensation aerosols and methods of making and using them 3 2009
* 2010/0300,433 Substrates for Enhancing Purity or Yield of Compounds Forming a Condensation Aerosol 8 2010
9308208 Aerosol generating method and device 0 2010
9211382 Drug condensation aerosols and kits 0 2012
8991387 Self-contained heating unit and drug-supply unit employing same 1 2013
8955512 Method of forming an aerosol for inhalation delivery 1 2013
9439907 Method of forming an aerosol for inhalation delivery 0 2013
9440034 Drug condensation aerosols and kits 0 2013
9370629 Self-contained heating unit and drug-supply unit employing same 0 2015
 
PHILIP MORRIS USA INC. (1)
* 7743766 Aerosol generating devices and methods for generating aerosols having controlled particle sizes 1 2005
 
CHRYSALIS TECHNOLOGIES INCORPORATED (1)
* 2005/0205,084 Aerosol generating devices and methods for generating aerosols having controlled particle sizes 10 2005
 
BASBAUM, ALLAN (1)
* 2008/0064,725 INTRATHECAL ADMINISTRATION OF TRIPTAN COMPOSITIONS TO TREAT NON-MIGRAINE PAIN 2 2007
* Cited By Examiner