US Patent No: 6,759,029

Number of patents in Portfolio can not be more than 2000

Delivery of rizatriptan and zolmitriptan through an inhalation route

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ATTORNEY / AGENT: (SPONSORED)

Importance

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Abstract

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The present invention relates to the delivery of rizatriptan or zolmitriptan through an inhalation route. Specifically, it relates to aerosols containing rizatriptan or zolmitriptan that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of rizatriptan or zolmitriptan. In a method aspect of the present invention, either rizatriptan or zolmitriptan is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of rizatriptan or zolmitriptan, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering rizatriptan or zolmitriptan through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of rizatriptan or zolmitriptan; and, b) a device that forms a rizatriptan or zolmitriptan containing aerosol from the composition, for inhalation by the mammal.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ALEXZA PHARMACEUTICALS, INC.PALO ALTO, CA64

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hale, Ron L Woodside, CA 68 2712
Rabinowitz, Joshua D Mountain View, CA 143 8049
Solas, Dennis W San Francisco, CA 67 3730
Zaffaroni, Alejandro C Atherton, CA 107 6905

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (1)
6,591,839 Filter material for reducing harmful substances in tobacco smoke 116 2001
 
ALEXZA PHARMACEUTICALS, INC. (1)
2003/0032,638 Delivery of benzodiazepines through an inhalation route 123 2002
 
SANSA CORPORATION (BARBADOS) INC. (1)
6,102,036 Breath activated inhaler 158 1998
 
VAPIR, INC. (1)
6,095,153 Vaporization of volatile materials 205 1998
 
ALLIANCE PHARMACEUTICAL CORP. (1)
* 6,041,777 Methods and apparatus for closed-circuit ventilation therapy 228 1995
 
CIVITAS THERAPEUTICS, INC. (1)
* 6,514,482 Pulmonary delivery in treating disorders of the central nervous system 160 2000
 
ARADIGM CORPORATION (7)
5,544,646 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 208 1994
5,957,124 Dynamic particle size control for aerosolized drug delivery 177 1995
5,694,919 Lockout device for controlled release of drug from patient-activated dispenser 200 1995
5,915,378 Creating an aerosolized formulation of insulin 147 1995
5,934,272 Device and method of creating aerosolized mist of respiratory drug 257 1995
5,960,792 Device for aerosolized delivery of peptide drugs 191 1995
5,735,263 Lockout device for controlled release of drug from patient-activated dispenser 205 1996
 
NOVARTIS PHARMA AG (1)
5,758,637 Liquid dispensing apparatus and methods 213 1996
 
R. J. REYNOLDS TOBACCO COMPANY (1)
5,388,574 Aerosol delivery article 193 1993
 
PFIZER INC. (1)
* 6,255,334 5HT 1 receptor agonists and metoclopramide for the treatment of migraine 102 1999
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
ALEXZA PHARMACEUTICALS, INC. (56)
* 7,766,013 Aerosol generating method and device 12 2001
7,942,147 Aerosol forming device for use in inhalation therapy 9 2002
7,537,009 Method of forming an aerosol for inhalation delivery 17 2002
7,458,374 Method and apparatus for vaporizing a compound 61 2002
8,003,080 Delivery of drug amines through an inhalation route 11 2003
* 2004/0009,128 Delivery of drug amines through an inhalation route 97 2003
7,913,688 Inhalation device for producing a drug aerosol 38 2003
8,288,372 Method for treating headache with loxapine 6 2003
7,402,777 Stable initiator compositions and igniters 25 2004
* 2004/0234,916 Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same 52 2004
7,540,286 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 22 2004
7,581,540 Aerosol drug delivery device incorporating percussively activated heat packages 19 2004
7,442,368 Delivery of stimulants through an inhalation route 18 2006
7,498,019 Delivery of compounds for the treatment of headache through an inhalation route 14 2006
7,449,172 Delivery of antiemetics through an inhalation route 17 2006
7,465,435 Delivery of beta-blockers through an inhalation route 15 2006
7,465,436 Delivery of compounds for the treatment of Parkinson's through an inhalation route 15 2006
7,485,285 Delivery of antidepressants through an inhalation route 15 2006
7,449,173 Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route 21 2006
7,465,437 Delivery of anti-migraine compounds through an inhalation route 15 2006
7,524,484 Delivery of diphenhydramine through an inhalation route 13 2006
7,507,398 Delivery of physiologically active compounds through an inhalation route 43 2006
* 7,449,174 Delivery of analgesics through an inhalation route 17 2006
* 7,449,175 Delivery of erectile dysfunction drugs through an inhalation route 18 2006
* 2006/0251,588 Delivery of erectile dysfunction drugs through an inhalation route 32 2006
7,601,337 Delivery of antipsychotics through an inhalation route 11 2006
7,488,469 Delivery of caffeine through an inhalation route 15 2006
* 2006/0280,692 Delivery of antipsychotics through an inhalation route 42 2006
* 2006/0257,329 Delivery of drug esters through an inhalation route 50 2006
7,510,702 Delivery of nonsteroidal antiinflammatory drugs through an inhalation route 14 2006
7,470,421 Delivery of diazepam through an inhalation route 18 2006
* 7,445,768 Delivery of sedative-hypnotics through an inhalation route 19 2006
7,491,047 Delivery of antihistamines through an inhalation route 15 2006
7,507,397 Delivery of muscle relaxants through an inhalation route 15 2006
7,468,179 Delivery of opioids through an inhalation route 33 2007
7,981,401 Diuretic aerosols and methods of making and using them 7 2007
* 2008/0299,048 MIXED DRUG AEROSOL COMPOSITIONS 15 2007
7,923,662 Stable initiator compositions and igniters 9 2008
7,988,952 Delivery of drug esters through an inhalation route 6 2008
8,235,037 Drug condensation aerosols and kits 6 2008
7,834,295 Printable igniters 8 2008
* 2010/0065,052 Heating Units 9 2008
7,987,846 Method and apparatus for vaporizing a compound 6 2008
8,173,107 Delivery of antipsychotics through an inhalation route 6 2009
8,074,644 Method of forming an aerosol for inhalation delivery 8 2009
8,333,197 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 6 2009
8,387,612 Self-contained heating unit and drug-supply unit employing same 8 2009
8,506,935 Respiratory drug condensation aerosols and methods of making and using them 3 2009
* 2010/0300,433 Substrates for Enhancing Purity or Yield of Compounds Forming a Condensation Aerosol 8 2010
9,308,208 Aerosol generating method and device 0 2010
9,211,382 Drug condensation aerosols and kits 0 2012
8,991,387 Self-contained heating unit and drug-supply unit employing same 1 2013
8,955,512 Method of forming an aerosol for inhalation delivery 1 2013
9,439,907 Method of forming an aerosol for inhalation delivery 0 2013
9,440,034 Drug condensation aerosols and kits 0 2013
9,370,629 Self-contained heating unit and drug-supply unit employing same 0 2015
 
PHILIP MORRIS USA INC. (1)
* 7,743,766 Aerosol generating devices and methods for generating aerosols having controlled particle sizes 1 2005
 
CHRYSALIS TECHNOLOGIES INCORPORATED (1)
* 2005/0205,084 Aerosol generating devices and methods for generating aerosols having controlled particle sizes 9 2005
 
BASBAUM, ALLAN (1)
* 2008/0064,725 INTRATHECAL ADMINISTRATION OF TRIPTAN COMPOSITIONS TO TREAT NON-MIGRAINE PAIN 2 2007
* Cited By Examiner