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Abstract

(E)-styryl benzylsulfones of formula I are useful as anticancer agents: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are independently selected from the group consisting of hydrogen, fluoro, chloro, iodo, bromo, C1-C6 alkyl, C1-C4 alkoxy, nitro, cyano and trifluoromethyl, with the proviso that (a) R.sub.1, R.sub.2, and R.sub.3 not all hydrogen when R.sub.4 is 2-chloro or 4-chloro; (b) when R.sub.1 and R.sub.3 are hydrogen and R.sub.2 is 4-bromo or 4-chloro, then R.sub.4 may not be 4-chloro, 4-fluoro or 4-bromo; (c) when R.sub.1 and R.sub.3 are hydrogen and R.sub.2 is 4-fluoro, then R.sub.4 may not be 4-fluoro or 4-bromo; (d) when R.sub.1 is hydrogen, and R.sub.4 is 2-fluoro, the R.sub.2 and R.sub.3 may not be 4-fluoro; and (e) when R.sub.1 is hydrogen and R.sub.3 is 4-hydrogen, 4-chloro, 4-bromo, 4-methyl or 4-methoxy, and R.sub.4 is 2-hydrogen, 2-chloro, or 2-fluoro; then R.sub.2 may not be 4-hydrogen, 4-chloro, 4-fluoro, or 4-bromo.

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