Matrix assisted laser ionization system
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United States of America Patent
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Jul 13, 2004
Grant Date -
N/A
app pub date -
May 30, 2003
filing date -
May 30, 2003
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A matrix assisted laser desorption and ionization system is provided. The system includes a mass spectrometer for analyzing at least one sample. The mass spectrometer includes a sample receiving chamber for receiving a sample under a vacuum. A UV laser is provided for producing a UV beam along a first beam path that does not intersect with the sample. A beam expander is provided in optical communication with the UV laser beam to expand the diameter of the beam. A focusing system is provided in optical communication with the beam expander to focus the laser beam propagating from the beam expander to a predetermined minimum spot size. The focusing system is located along the path of the beam propagating from the beam expander so that the beam strikes the approximate optical center of the focusing system. A high reflecting mirror is provided in optical communication with the focused beam propagating from the focusing system to direct the focused beam to strike the sample at a preselected strike point. Desirably, the laser, the beam expander and the focusing system, preferably a lens, are mounted to the same mounting surface or to parallel mounting surfaces that are joined together to form an integral structure.
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