Compounds useful for treatment or prevention of disease mediated by alpha-2B-adrenoceptor
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United States of America Patent
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Jul 27, 2004
Grant Date -
Apr 17, 2003
app pub date -
Jul 17, 2002
filing date -
Jul 20, 2001
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A compound, suitable as an alpha-2B-adrenoceptor antagoist, having a structure of formula (I) ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are independently of each other H, a straight or branched alkyl or alkoxy group with 1 to 4 carbon atoms, or a halogen; X is H, a straight or branched alkyl chain with 1 to 4 carbon atoms, phenyl, --OH or .dbd.O; Z is H, acetyl, --CH.sub.2 --Ph--O--CF.sub.3 or --CH.sub.2 --Ph--CF.sub.3, Y is a ring structure optionally linked to formula (I) with an alkyl chain having one or two carbon atoms. The compound is suitable for use in a method for treatment or prevention of a disease mediated by the alpha-2B-adrenoceptor in a mammal.
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