Importance

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Abstract

An affinity ligand-matrix conjugate comprises the matrix and, conjugated thereto by the group Z, a ligand having general formula (I) wherein on X is N and the other X is N, CCL or CCn; A.sub.1 and A.sub.2 are each independently O, S or N--R.sub.1 and R.sub.1 is H, C.sub.1-6 alkyl, C.sub.1-6 hydroxyalkyl, benzyl or .beta.-phenylethyl; B.sub.1 and B.sub.2 are each independently an optionally substituted hydrocarbon lingkage containing from 1 to 10 carbon atoms; D.sub.1 is H or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; and D.sub.2 is a secondary amino, tertiary amino, quaternary ammonium, imadazole, guanidino or amidino group; of B.sub.2 -D.sub.2 is --CHCOOH--(CH.sub.2).sub.3-4 --NH.sub.2 ; AND p is 0 or 1. Such conjugates are useful for the separation, isolation, purification, characterisation, identification or quantification of an endotoxin. ##STR1##

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First Claim