Extracorporeal endotoxin removal method
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United States of America Patent
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Aug 10, 2004
Grant Date -
N/A
app pub date -
Sep 15, 2000
filing date -
Sep 29, 1999
priority date (Note) -
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Abstract
This invention describes blood treating material having the capacity to selectively remove endotoxin and cytokine inducing substances from blood or plasma by extracorporeal adsorption for therapeutic septic shock treatment. The endotoxin adsorption ligands of the invention are oligopeptides synthesized from amino acids having a pk>7.2 such as arginine, lysine or histidine, using a polycondensation step such that the resultant oligopeptides exhibit a high degree of polydispersity. Also provided are methods and devices using an adsorbent having a polydisperse oligopeptide of the invention immobilized on a solid state support medium for removing endotoxin from the blood of human or animal subject.
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