Therapeutic uses of factors which inhibit or neutralize MIF activity
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United States of America Patent
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Aug 10, 2004
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app pub date -
Oct 24, 1996
filing date -
May 17, 1993
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Abstract
The present invention relates to methods of treating disorders related to cellular overproliferation comprising neutralizing the production or activity of macrophage migration inhibitory factor (MIF). The invention also relates to therapeutic compositions comprising factors which inhibit or neutralize MIF activity, such as, MIF antisense RNA molecules and MIF monoclonal antibodies and derivatives or analogs thereof. The invention further relates to the uses of such compositions and methods for the treatment of malignancies, including, but not limited to, B and T cell lymphomas.
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