Tetra-aza macrocycles and metal complexes thereof
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United States of America Patent
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Aug 10, 2004
Grant Date -
N/A
app pub date -
Aug 31, 1990
filing date -
Aug 12, 1987
priority date (Note) -
Expired
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Abstract
1,4,7,10-Tetrazacyclododecanes carrying a side chain terminating in a group capable of reacting with an antibody, and their complexes with a di- or tripositive metal having a coordination number of 6 or more can be used to prepare imaging agents. Typical metals are indium, copper, lead, bismuth, yttrium, terbium, gadolinium, and scandium. The compounds can be reacted with a monoclonal or polyclonal antibody or antibody fragment to target the metal to a specific type of tissue.
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