US Patent No: 6,776,978

Number of patents in Portfolio can not be more than 2000

Delivery of opioids through an inhalation route

Stats

ALSO PUBLISHED AS: 20030017119
ATTORNEY / AGENT: (SPONSORED)
 

Importance

Loading Importance Indicators... loading....

Abstract

The present invention relates to the delivery of opioids through an inhalation route. Specifically, it relates to aerosols containing opioids that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an opioid. In a method aspect of the present invention, an opioid is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an opioid, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an opioid through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an opioid; and, b) a device that forms an opioid aerosol from the composition, for inhalation by the mammal.

Loading the Abstract Image... loading....

First Claim

Related Publications

Loading Related Publications... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
ALEXZA PHARMACEUTICALS, INC.PALO ALTO, CA113

International Classification(s)

  • [Classification Symbol]
  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Rabinowitz, Joshua D Mountain View, CA 158 4466
Zaffaroni, Alejandro C Atherton, CA 120 3735

Cited Art

Patent Info (Count) # Cites Year
 
ARADIGM CORPORATION (9)
5,544,646 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 191 1994
5,724,957 Intrapulmonary delivery of narcotics 137 1995
5,957,124 Dynamic particle size control for aerosolized drug delivery 162 1995
5,694,919 Lockout device for controlled release of drug from patient-activated dispenser 153 1995
5,915,378 Creating an aerosolized formulation of insulin 135 1995
5,934,272 Device and method of creating aerosolized mist of respiratory drug 173 1995
5,960,792 Device for aerosolized delivery of peptide drugs 165 1995
5,735,263 Lockout device for controlled release of drug from patient-activated dispenser 167 1996
5,910,301 Method of intrapulmonary administration of a narcotic drug 38 1997
 
3M COMPANY (1)
5,655,523 Dry powder inhalation device having deagglomeration/aerosolization structure responsive to patient inhalation 143 1995
 
ADVANCED INHALATIONS REVOLUTIONS, INC. (1)
6,095,153 Vaporization of volatile materials 150 1998
 
ALEXZA PHARMACEUTICALS, INC. (1)
2003/0032,638 Delivery of benzodiazepines through an inhalation route 110 2002
 
ALLIANCE PHARMACEUTICAL CORP. (1)
6,041,777 Methods and apparatus for closed-circuit ventilation therapy 166 1995
 
CIVITAS THERAPEUTICS, INC. (1)
6,514,482 Pulmonary delivery in treating disorders of the central nervous system 123 2000
 
EASTERN TECHNOLOGY SEED INVESTMENT FUND LIMITED PARTNERSHIP (1)
5,451,408 Pain management with liposome-encapsulated analgesic drugs 51 1994
 
NICO PUFF CORPORATION (1)
6,102,036 Breath activated inhaler 133 1998
 
NOVARTIS PHARMA AG (1)
5,758,637 Liquid dispensing apparatus and methods 170 1996
 
NUVO RESEARCH INC. (1)
6,306,431 Apparatus for heating to a desired temperature for improved administration of pharmaceutically active compounds 67 2000
 
R. J. REYNOLDS TOBACCO COMPANY (1)
5,388,574 Aerosol delivery article 135 1993
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (3)
RE30285 Spraying devices, in particular nebulizing devices 112 1977
5,543,434 Nasal administration of ketamine to manage pain 57 1994
6,591,839 Filter material for reducing harmful substances in tobacco smoke 107 2001

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ALEXZA PHARMACEUTICALS, INC. (42)
7,766,013 Aerosol generating method and device 3 2001
7,942,147 Aerosol forming device for use in inhalation therapy 0 2002
7,537,009 Method of forming an aerosol for inhalation delivery 6 2002
7,458,374 Method and apparatus for vaporizing a compound 12 2002
6,855,310 Delivery of analgesics through an inhalation route 44 2002
8,003,080 Delivery of drug amines through an inhalation route 0 2003
7,913,688 Inhalation device for producing a drug aerosol 0 2003
8,288,372 Method for treating headache with loxapine 0 2003
7,169,378 Delivery of opioids through an inhalation route 45 2004
7,402,777 Stable initiator compositions and igniters 17 2004
7,540,286 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 7 2004
7,581,540 Aerosol drug delivery device incorporating percussively activated heat packages 5 2004
7,442,368 Delivery of stimulants through an inhalation route 10 2006
7,498,019 Delivery of compounds for the treatment of headache through an inhalation route 6 2006
7,449,172 Delivery of antiemetics through an inhalation route 9 2006
7,465,435 Delivery of beta-blockers through an inhalation route 7 2006
7,465,436 Delivery of compounds for the treatment of Parkinson's through an inhalation route 7 2006
7,485,285 Delivery of antidepressants through an inhalation route 7 2006
7,449,173 Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route 10 2006
7,465,437 Delivery of anti-migraine compounds through an inhalation route 7 2006
7,524,484 Delivery of diphenhydramine through an inhalation route 5 2006
7,507,398 Delivery of physiologically active compounds through an inhalation route 15 2006
7,449,174 Delivery of analgesics through an inhalation route 9 2006
7,449,175 Delivery of erectile dysfunction drugs through an inhalation route 10 2006
7,601,337 Delivery of antipsychotics through an inhalation route 3 2006
7,488,469 Delivery of caffeine through an inhalation route 7 2006
7,510,702 Delivery of nonsteroidal antiinflammatory drugs through an inhalation route 6 2006
7,470,421 Delivery of diazepam through an inhalation route 8 2006
7,445,768 Delivery of sedative-hypnotics through an inhalation route 9 2006
7,491,047 Delivery of antihistamines through an inhalation route 7 2006
7,507,397 Delivery of muscle relaxants through an inhalation route 7 2006
7,468,179 Delivery of opioids through an inhalation route 11 2007
7,981,401 Diuretic aerosols and methods of making and using them 0 2007
7,923,662 Stable initiator compositions and igniters 1 2008
7,988,952 Delivery of drug esters through an inhalation route 0 2008
8,235,037 Drug condensation aerosols and kits 0 2008
7,834,295 Printable igniters 1 2008
7,987,846 Method and apparatus for vaporizing a compound 0 2008
8,173,107 Delivery of antipsychotics through an inhalation route 0 2009
8,074,644 Method of forming an aerosol for inhalation delivery 0 2009
8,333,197 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 0 2009
8,387,612 Self-contained heating unit and drug-supply unit employing same 0 2009
 
ACELRX PHARMACEUTICALS, INC. (4)
8,357,114 Drug dispensing device with flexible push rod 0 2007
8,252,328 Bioadhesive drug formulations for oral transmucosal delivery 0 2007
8,252,329 Bioadhesive drug formulations for oral transmucosal delivery 0 2007
8,231,900 Small-volume oral transmucosal dosage 0 2007
 
DEPUY SPINE, INC. (1)
8,142,503 Devices and methods for facilitating controlled bone growth or repair 0 2006
 
HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (1)
7,827,983 Method for making a pharmaceutically active ingredient abuse-prevention device 0 2004

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
11.5 Year Payment $7400.00 $3700.00 $1850.00 Feb 17, 2016
Fee Large entity fee small entity fee micro entity fee
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00