US Patent No: 6,776,978

Number of patents in Portfolio can not be more than 2000

Delivery of opioids through an inhalation route

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to the delivery of opioids through an inhalation route. Specifically, it relates to aerosols containing opioids that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an opioid. In a method aspect of the present invention, an opioid is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an opioid, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an opioid through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an opioid; and, b) a device that forms an opioid aerosol from the composition, for inhalation by the mammal.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ALEXZA PHARMACEUTICALS, INC.PALO ALTO, CA64

International Classification(s)

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Rabinowitz, Joshua D Mountain View, CA 143 8023
Zaffaroni, Alejandro C Atherton, CA 107 6889

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (2)
5,543,434 Nasal administration of ketamine to manage pain 70 1994
6,591,839 Filter material for reducing harmful substances in tobacco smoke 116 2001
 
ALEXZA PHARMACEUTICALS, INC. (1)
2003/0032,638 Delivery of benzodiazepines through an inhalation route 123 2002
 
SANSA CORPORATION (BARBADOS) INC. (1)
6,102,036 Breath activated inhaler 157 1998
 
VAPIR, INC. (1)
6,095,153 Vaporization of volatile materials 202 1998
 
NUVO RESEARCH INC. (1)
6,306,431 Apparatus for heating to a desired temperature for improved administration of pharmaceutically active compounds 84 2000
 
ALLIANCE PHARMACEUTICAL CORP. (1)
* 6,041,777 Methods and apparatus for closed-circuit ventilation therapy 225 1995
 
CIVITAS THERAPEUTICS, INC. (1)
* 6,514,482 Pulmonary delivery in treating disorders of the central nervous system 159 2000
 
ARADIGM CORPORATION (9)
5,544,646 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 207 1994
5,724,957 Intrapulmonary delivery of narcotics 186 1995
5,957,124 Dynamic particle size control for aerosolized drug delivery 177 1995
5,694,919 Lockout device for controlled release of drug from patient-activated dispenser 199 1995
5,915,378 Creating an aerosolized formulation of insulin 147 1995
5,934,272 Device and method of creating aerosolized mist of respiratory drug 249 1995
5,960,792 Device for aerosolized delivery of peptide drugs 191 1995
5,735,263 Lockout device for controlled release of drug from patient-activated dispenser 204 1996
5,910,301 Method of intrapulmonary administration of a narcotic drug 51 1997
 
EASTERN TECHNOLOGY SEED INVESTMENT FUND LIMITED PARTNERSHIP (1)
5,451,408 Pain management with liposome-encapsulated analgesic drugs 72 1994
 
NOVARTIS PHARMA AG (1)
5,758,637 Liquid dispensing apparatus and methods 213 1996
 
R. J. REYNOLDS TOBACCO COMPANY (1)
5,388,574 Aerosol delivery article 190 1993
 
ADAMIS PHARMACEUTICALS CORPORATION (1)
5,655,523 Dry powder inhalation device having deagglomeration/aerosolization structure responsive to patient inhalation 192 1995
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
DEPUY SPINE, INC. (2)
8,142,503 Devices and methods for facilitating controlled bone growth or repair 25 2006
* 2007/0083,265 Devices and methods for facilitating controlled bone growth or repair 74 2006
 
ALEXZA PHARMACEUTICALS, INC. (60)
* 7,766,013 Aerosol generating method and device 12 2001
7,942,147 Aerosol forming device for use in inhalation therapy 9 2002
7,537,009 Method of forming an aerosol for inhalation delivery 17 2002
7,458,374 Method and apparatus for vaporizing a compound 56 2002
* 6,855,310 Delivery of analgesics through an inhalation route 66 2002
* 2003/0017,117 Delivery of analgesics through an inhalation route 47 2002
8,003,080 Delivery of drug amines through an inhalation route 11 2003
* 2004/0009,128 Delivery of drug amines through an inhalation route 97 2003
7,913,688 Inhalation device for producing a drug aerosol 34 2003
8,288,372 Method for treating headache with loxapine 6 2003
* 7,169,378 Delivery of opioids through an inhalation route 61 2004
* 2004/0202,617 Delivery of opioids through an inhalation route 14 2004
7,402,777 Stable initiator compositions and igniters 25 2004
* 2005/0258,159 Stable initiator compositions and igniters 34 2004
* 2004/0234,916 Optically ignited or electrically ignited self-contained heating unit and drug-supply unit employing same 52 2004
7,540,286 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 22 2004
* 2005/0034,723 Substrates for drug delivery device and methods of preparing and use 57 2004
7,581,540 Aerosol drug delivery device incorporating percussively activated heat packages 19 2004
7,442,368 Delivery of stimulants through an inhalation route 18 2006
7,498,019 Delivery of compounds for the treatment of headache through an inhalation route 14 2006
7,449,172 Delivery of antiemetics through an inhalation route 17 2006
7,465,435 Delivery of beta-blockers through an inhalation route 15 2006
7,465,436 Delivery of compounds for the treatment of Parkinson's through an inhalation route 15 2006
7,485,285 Delivery of antidepressants through an inhalation route 15 2006
7,449,173 Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route 21 2006
7,465,437 Delivery of anti-migraine compounds through an inhalation route 15 2006
7,524,484 Delivery of diphenhydramine through an inhalation route 13 2006
7,507,398 Delivery of physiologically active compounds through an inhalation route 42 2006
* 7,449,174 Delivery of analgesics through an inhalation route 17 2006
* 7,449,175 Delivery of erectile dysfunction drugs through an inhalation route 18 2006
* 2006/0251,588 Delivery of erectile dysfunction drugs through an inhalation route 32 2006
7,601,337 Delivery of antipsychotics through an inhalation route 11 2006
7,488,469 Delivery of caffeine through an inhalation route 15 2006
* 2006/0280,692 Delivery of antipsychotics through an inhalation route 42 2006
* 2006/0257,329 Delivery of drug esters through an inhalation route 50 2006
7,510,702 Delivery of nonsteroidal antiinflammatory drugs through an inhalation route 14 2006
7,470,421 Delivery of diazepam through an inhalation route 18 2006
* 7,445,768 Delivery of sedative-hypnotics through an inhalation route 19 2006
7,491,047 Delivery of antihistamines through an inhalation route 15 2006
7,507,397 Delivery of muscle relaxants through an inhalation route 15 2006
7,468,179 Delivery of opioids through an inhalation route 33 2007
7,981,401 Diuretic aerosols and methods of making and using them 7 2007
7,923,662 Stable initiator compositions and igniters 9 2008
7,988,952 Delivery of drug esters through an inhalation route 6 2008
8,235,037 Drug condensation aerosols and kits 6 2008
7,834,295 Printable igniters 8 2008
7,987,846 Method and apparatus for vaporizing a compound 6 2008
8,173,107 Delivery of antipsychotics through an inhalation route 6 2009
8,074,644 Method of forming an aerosol for inhalation delivery 8 2009
8,333,197 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 6 2009
8,387,612 Self-contained heating unit and drug-supply unit employing same 8 2009
8,506,935 Respiratory drug condensation aerosols and methods of making and using them 3 2009
* 2010/0300,433 Substrates for Enhancing Purity or Yield of Compounds Forming a Condensation Aerosol 8 2010
9,308,208 Aerosol generating method and device 0 2010
9,211,382 Drug condensation aerosols and kits 0 2012
8,991,387 Self-contained heating unit and drug-supply unit employing same 1 2013
8,955,512 Method of forming an aerosol for inhalation delivery 1 2013
9,439,907 Method of forming an aerosol for inhalation delivery 0 2013
9,440,034 Drug condensation aerosols and kits 0 2013
9,370,629 Self-contained heating unit and drug-supply unit employing same 0 2015
 
HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (2)
7,827,983 Method for making a pharmaceutically active ingredient abuse-prevention device 0 2004
* 2006/0130,829 Inhalation device 3 2004
 
DEPUY SYNTHES PRODUCTS, LLC (3)
8,617,246 Devices and methods for facilitating controlled bone growth or repair 2 2010
8,523,908 Devices and methods for facilitating controlled bone growth or repair 12 2012
8,906,093 Devices and methods for facilitating controlled bone growth or repair 0 2013
 
ANTIOP, INC. (2)
9,192,570 Intranasal naloxone compositions and methods of making and using same 1 2014
9,289,425 Intranasal naloxone compositions and methods of making and using same 0 2015
 
ACELRX PHARMACEUTICALS, INC. (21)
* 2007/0299,687 Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed 18 2006
8,357,114 Drug dispensing device with flexible push rod 12 2007
8,252,328 Bioadhesive drug formulations for oral transmucosal delivery 5 2007
* 2007/0186,923 Drug storage and dispensing devices and systems comprising the same 87 2007
9,066,847 Storage and dispensing devices for administration of oral transmucosal dosage forms 0 2007
8,252,329 Bioadhesive drug formulations for oral transmucosal delivery 5 2007
* 2008/0166,404 Bioadhesive drug formulations for oral transmucosal delivery 17 2007
8,231,900 Small-volume oral transmucosal dosage 5 2007
9,289,583 Methods for administering small volume oral transmucosal dosage forms using a dispensing device 0 2007
8,865,743 Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain 2 2007
8,499,966 Method of moving a delivery member of a dispensing device for administration of oral transmucosal dosage forms 5 2007
8,945,592 Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same 2 2008
8,548,623 Storage and dispensing devices for administration of oral transmucosal dosage forms 0 2010
8,535,714 Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain 5 2011
8,574,189 Storage and dispensing devices for administration of oral transmucosal dosage forms 2 2012
8,778,393 Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain 3 2012
8,778,394 Small-volume oral transmucosal dosage forms 3 2012
8,865,211 Bioadhesive drug formulations for oral transmucosal delivery 2 2012
8,753,308 Methods for administering small volume oral transmucosal dosage forms using a dispensing device 7 2012
8,905,964 Drug storage and dispensing devices and systems comprising the same 1 2013
9,320,710 Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain 0 2014
* Cited By Examiner