Microbial transformation method for the preparation of an epothilone
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United States of America Patent
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Aug 24, 2004
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app pub date -
Dec 21, 1999
filing date -
Dec 23, 1998
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Abstract
A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said alkyl group to a hydroxyalkyl group, and effecting said hydroxylation.
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