US Patent No: 6,783,753

Number of patents in Portfolio can not be more than 2000

Delivery of antidepressants through an inhalation route

ALSO PUBLISHED AS: 20030206869

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Abstract

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The present invention relates to the delivery of antidepressants through an inhalation route. Specifically, it relates to aerosols containing an antidepressant that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an antidepressant. In a method aspect of the present invention, an antidepressant is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an antidepressant to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an antidepressant through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an antidepressant; and, b) a device that forms an antidepressant containing aerosol from the composition, for inhalation by the mammal.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
ALEXZA PHARMACEUTICALS, INC.PALO ALTO, CA114

International Classification(s)

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  • [Patents Count]

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Rabinowitz, Joshua D Mountain View, CA 244 6695
Zaffaroni, Alejandro C Atherton, CA 197 5908

Cited Art Landscape

Patent Info (Count) # Cites Year
 
ARADIGM CORPORATION (7)
5,544,646 Systems for the intrapulmonary delivery of aerosolized aqueous formulations 195 1994
5,957,124 Dynamic particle size control for aerosolized drug delivery 165 1995
5,694,919 Lockout device for controlled release of drug from patient-activated dispenser 171 1995
5,915,378 Creating an aerosolized formulation of insulin 135 1995
5,934,272 Device and method of creating aerosolized mist of respiratory drug 199 1995
5,960,792 Device for aerosolized delivery of peptide drugs 176 1995
5,735,263 Lockout device for controlled release of drug from patient-activated dispenser 178 1996
 
ADAMIS PHARMACEUTICALS CORPORATION (1)
5,655,523 Dry powder inhalation device having deagglomeration/aerosolization structure responsive to patient inhalation 154 1995
 
ADVANCED INHALATIONS REVOLUTIONS, INC. (1)
6,095,153 Vaporization of volatile materials 160 1998
 
ALEXZA PHARMACEUTICALS, INC. (1)
2003/0032,638 Delivery of benzodiazepines through an inhalation route 116 2002
 
ALLIANCE PHARMACEUTICAL CORP. (1)
6,041,777 Methods and apparatus for closed-circuit ventilation therapy 189 1995
 
CIVITAS THERAPEUTICS, INC. (1)
6,514,482 Pulmonary delivery in treating disorders of the central nervous system 131 2000
 
NICO PUFF CORPORATION (1)
6,102,036 Breath activated inhaler 141 1998
 
NOVARTIS PHARMA AG (1)
5,758,637 Liquid dispensing apparatus and methods 191 1996
 
NUVO RESEARCH INC. (1)
6,306,431 Apparatus for heating to a desired temperature for improved administration of pharmaceutically active compounds 70 2000
 
R. J. REYNOLDS TOBACCO COMPANY (1)
5,388,574 Aerosol delivery article 147 1993
 
THE GENERAL HOSPITAL CORPORATION (1)
6,420,351 Methods for treating neuropsychiatric disorders 34 2001
 
UNIVERSITY OF WALES COLLEGE OF CARDIFF (1)
5,292,499 Method of preparing medical aerosol formulations including drug dissolved in reverse micelles 61 1992
 
Other [Check patent profile for assignment information] (3)
RE30285 Spraying devices, in particular nebulizing devices 114 1977
6,140,323 Dosing method of administering medicaments via inhalation administration or skin administration 41 1999
6,591,839 Filter material for reducing harmful substances in tobacco smoke 109 2001

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
ALEXZA PHARMACEUTICALS, INC. (43)
7,766,013 Aerosol generating method and device 5 2001
7,942,147 Aerosol forming device for use in inhalation therapy 0 2002
7,537,009 Method of forming an aerosol for inhalation delivery 8 2002
7,458,374 Method and apparatus for vaporizing a compound 25 2002
8,003,080 Delivery of drug amines through an inhalation route 0 2003
7,913,688 Inhalation device for producing a drug aerosol 3 2003
8,288,372 Method for treating headache with loxapine 0 2003
7,029,658 Delivery of antidepressants through an inhalation route 41 2003
7,060,254 Delivery of antidepressants through an inhalation route 41 2004
7,402,777 Stable initiator compositions and igniters 18 2004
7,540,286 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 8 2004
7,581,540 Aerosol drug delivery device incorporating percussively activated heat packages 6 2004
7,442,368 Delivery of stimulants through an inhalation route 11 2006
7,498,019 Delivery of compounds for the treatment of headache through an inhalation route 7 2006
7,449,172 Delivery of antiemetics through an inhalation route 10 2006
7,465,435 Delivery of beta-blockers through an inhalation route 8 2006
7,465,436 Delivery of compounds for the treatment of Parkinson's through an inhalation route 8 2006
7,485,285 Delivery of antidepressants through an inhalation route 8 2006
7,449,173 Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route 12 2006
7,465,437 Delivery of anti-migraine compounds through an inhalation route 8 2006
7,524,484 Delivery of diphenhydramine through an inhalation route 6 2006
7,507,398 Delivery of physiologically active compounds through an inhalation route 22 2006
7,449,174 Delivery of analgesics through an inhalation route 10 2006
7,449,175 Delivery of erectile dysfunction drugs through an inhalation route 11 2006
7,601,337 Delivery of antipsychotics through an inhalation route 4 2006
7,488,469 Delivery of caffeine through an inhalation route 8 2006
7,510,702 Delivery of nonsteroidal antiinflammatory drugs through an inhalation route 7 2006
7,470,421 Delivery of diazepam through an inhalation route 10 2006
7,445,768 Delivery of sedative-hypnotics through an inhalation route 11 2006
7,491,047 Delivery of antihistamines through an inhalation route 8 2006
7,507,397 Delivery of muscle relaxants through an inhalation route 8 2006
7,468,179 Delivery of opioids through an inhalation route 19 2007
7,981,401 Diuretic aerosols and methods of making and using them 0 2007
7,923,662 Stable initiator compositions and igniters 1 2008
7,988,952 Delivery of drug esters through an inhalation route 0 2008
8,235,037 Drug condensation aerosols and kits 0 2008
7,834,295 Printable igniters 1 2008
7,987,846 Method and apparatus for vaporizing a compound 0 2008
8,173,107 Delivery of antipsychotics through an inhalation route 0 2009
8,074,644 Method of forming an aerosol for inhalation delivery 0 2009
8,333,197 Multiple dose condensation aerosol devices and methods of forming condensation aerosols 0 2009
8,387,612 Self-contained heating unit and drug-supply unit employing same 0 2009
8,506,935 Respiratory drug condensation aerosols and methods of making and using them 0 2009
 
THE INVENTION SCIENCE FUND I, LLC (5)
8,725,529 Methods and systems for presenting an inhalation experience 0 2009
8,706,518 Methods and systems for presenting an inhalation experience 0 2009
8,694,330 Methods and systems for presenting an inhalation experience 0 2009
8,738,395 Methods and systems for presenting an inhalation experience 0 2009
8,712,794 Methods and systems for presenting an inhalation experience 0 2009

Maintenance Fees

Fee Large entity fee small entity fee micro entity fee due date
11.5 Year Payment $7400.00 $3700.00 $1850.00 Feb 29, 2016
Fee Large entity fee small entity fee micro entity fee
Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
Surcharge after expiration - Late payment is unintentional $1,640.00 $820.00 $410.00