Reversing advanced glycosylation cross-links using heterocyclic-substituted thiazolium compounds

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United States of America Patent

PATENT NO 6790859
SERIAL NO

10348378

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Abstract

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The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.

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Patent Owner(s)

Patent OwnerAddress
ALTEON INCORPORATEDPARSIPPANY NJ

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cerami, Anthony New York, NY 213 4234
Egan, John J NY, NY 27 225
Fang, Sheng-Ding Mahwah, NJ 5 29
Rho, Taikyun Saddle Brook, NJ 5 22
Ulrich, Peter Old Tappan, NJ 42 546
Vasan, Sara Yonkers, NY 30 305
Wagle, Dilip R Nanuet, NY 37 313

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