Process for the preparation of 7-azabicyclo[4.1.0]hept-3-ene-3-carboxylic acid esters
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Sep 14, 2004
Grant Date -
N/A
app pub date -
Aug 13, 2002
filing date -
Nov 2, 1999
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The present invention provides a method of producing 7-azabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ester (VII) economically, industrially advantageously and efficiently in a large amount. The present invention relates to a production method of compound (VII), which includes reacting epoxide (I) with amine (II) to give aminodiol (III), reacting the aminodiol (III) with a sulfonylating agent in the presence of a base to give azabicyclohept-2-ene (IV), reacting the azabicyclohept-2-ene (IV) with alcohol (V) in the presence of a Lewis acid to give azabicyclohept-3-ene (VI), and eliminating the 7-position substituent R.sup.2 from the azabicyclohept-3-ene (VI) ##STR1##
First Claim
Family
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully