Process for purifying pravastatin sodium from a fermentation broth
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United States of America Patent
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Sep 14, 2004
Grant Date -
Aug 26, 2004
app pub date -
May 14, 2003
filing date -
Feb 21, 2003
priority date (Note) -
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Abstract
A process for purifying pravastatin sodium comprising the steps of: a. clarifying a fermentation broth containing pravastatin sodium to obtain a clear solution; and adjusting the clear solution to be basic having pH value ranging from pH 10.about.13; b. adsorbing the pravastatin sodium with non-ionic resin; eluting the pravastatin sodium by water-soluble organic solvent; and forming a concentrate of pravastatin sodium; c. treating the concentrate with water-soluble anti-solvent or inorganic salt to form a precipitate of pravastatin sodium; and d. recrystallizing the precipitate for making pravastatin sodium crystal with high purity and high yield.
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