Importance

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Abstract

Compounds of the formula ##STR1## or the 10,11-anhydro forms therefor, wherein R.sub.a is H or OH; R.sub.b is H or halogen; R.sub.c is H or a protecting group; R.sub.d is methyl; unsubstituted alkyl (3-10C); substituted alkyl (1-10C); substituted or unsubstituted alkenyl (2-10C) or substituted or unsubstituted alkynyl (2-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); substituted or unsubstituted arylalkenyl (5-20C); substituted or unsubstituted arylalkynyl (5-20C); substituted or unsubstituted amidoarylalkyl (5-20C); substituted or unsubstituted amidoarylalkenyl (5-20C); or substituted or unsubstituted amidoarylalkynyl (5-20C); R.sub.e is H or a protecting group or is mono- or disubstituted amino carbonyl; R.sub.f is H; substituted or unsubstituted alkyl (1-10C); substituted or unsubstituted alkenyl (1-10C); substituted or unsubstituted alkynyl (1-10C); substituted or unsubstituted aryl (4-14C); substituted or unsubstituted arylalkyl (5-20C); or --OR.sub.f may be replaced by --H; one of Z and Y is H and the other is OH or protected OH, or is amino, mono-or dialkyl-amino, protected amino, or an aminoheterocycle or Z and Y together are .dbd.O, .dbd.NOH or a derivatized oxime; including any pharmaceutically acceptable salts thereof and any stereoisomeric forms and mixtures of stereoisomeric forms thereof, are antimicrobial agents.

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First Claim