Methods, systems, and kits for intravascular nucleic acid delivery
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United States of America Patent
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Sep 21, 2004
Grant Date -
Feb 27, 2003
app pub date -
Aug 9, 2002
filing date -
Dec 31, 1997
priority date (Note) -
Expired
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Abstract
Nucleic acid transfection of vascular smooth muscle cells is enhanced by the application of vibrational energy to the cells. By applying vibrational energy at frequency in the range from 1 kHz to 10 MHz and at an intensity in the range from 0.01 W/cm.sup.2 to 100 W/cm.sup.2, significant enhancement of the uptake of nucleic acids into vascular smooth muscle cells can be achieved.
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