Purine inhibitors of cyclin dependent kinase 2 & ikappabalpha
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United States of America Patent
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Sep 21, 2004
Grant Date -
Mar 14, 2002
app pub date -
Aug 14, 2001
filing date -
Aug 2, 1996
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A compound having the formula: ##STR1## wherein: R.sub.1 is --X--R.sub.1 '; in which R.sub.1 ' is lower alkyl, substituted lower alkyl, aryl, substituted aryl, heteroaryl, or substituted heteroaryl, or heterocyclic, and X is --NH--; R.sub.2 is isopropyl; and R.sub.3 is --NR.sub.4 R.sub.5 ; in which R.sub.4 is hydrogen and R.sub.5 is lower alkyl substituted with amino or R.sub.4 and R.sub.5 are both lower alkyl substituted with one, two or three groups chosen from hydroxy and amino, or an acid addition salt or cationic salt thereof. The compounds inhibit CDK-2 activity and are useful for treating disorders characterized by undesirable cell proliferation.
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