Methods for removing dimethoxytrityl groups from oligonucleotides
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United States of America Patent
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Sep 21, 2004
Issued Date -
N/A
app pub date -
Mar 22, 2002
filing date -
Mar 17, 1999
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Abstract
The present invention discloses improved methods for oligonucleotide synthesis and purification. In the methods of the invention, a half-life is determined for deprotection of the 5'-OH protecting group at the 5'-terminus of an oligonucleotide post-synthesis. The half-life is used to determine an optimal reaction time for removal of the 5'-OH protecting group. The methods of the invention are amenable to the large-scale synthesis and purification of oligonucleotides.
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