Fluorescent cobalamins and uses thereof
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United States of America Patent
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Sep 28, 2004
Grant Date -
Dec 19, 2002
app pub date -
Mar 15, 2002
filing date -
Oct 26, 1999
priority date (Note) -
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Abstract
The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalamin. These fluorescent cobalamins can be used to as diagnostic and prognostic markers (a) to distinguish cancer cells and tissues from healthy cells and tissues, including identifying lymph nodes containing cancer cells, and (b) to determine if an individual will respond positively to chemotherapy using cobalamin-therapeutic bioconjugates.
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