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Abstract

Novel proteins which belong to the papain family and are cysteine proteinase enzymes (the cysteine proteinase enzymes are expected to be involved in the turnover of intracellular proteins, antigen presentation, prohormone activation, bone remodeling, etc. and to play important roles in a variety of pathological conditions such as Alzheimer's disease, pulmonary emphysema, rheumatoid arthritis, muscular dystrophy, osteoporosis, neurodegenerative disease, and cancer invasion and metastasis), together with genes encoding the proteins and antibodies against the proteins, can be conveniently used in elucidating the function of a cysteine proteinase involved in various diseases and disorders, especially cancers, thereby not only disclosing critical mechanism leading to such diseases and disorders but also researching and developing therapy and therapeutic drugs thereagainst. The novel cathepsin (especially, human cathepsin L2) is cloned from human cDNA library, thereby leading to, DNA containing a nucleotide sequence coding for the protein, host cells transformed with the DNA, processes for producing the human cathepsin L2 protein which comprise using the host cell, monoclonal antibodies which bind with the cathepsin L2 protein and use of the protein, antibodies and nucleic acids.

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First Claim