Recombinant adenoviruses expressing interleukin-18 protein and gene therapy using them
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United States of America Patent
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Oct 5, 2004
Grant Date -
Jul 31, 2003
app pub date -
Mar 22, 2002
filing date -
Dec 11, 2001
priority date (Note) -
Expired
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Abstract
The present invention relates to recombinant adenoviruses expressing interleukin-18 protein, and gene therapy using them. More particularly, the invention provides recombinant adenoviruses Ad.promIL-18, Ad.GMmIL-18, Ad.prohIL-18, Ad.hIL-18CPP32- and Ad.preprotrypsin.hIL-18CPP32- which are effectively capable of treating a variety of cancer cells by promoting and enhancing an immune response in vivo.
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