Methods for compositions for in vivo gene delivery
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United States of America Patent
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Oct 19, 2004
Issued Date -
N/A
app pub date -
Jun 10, 1998
filing date -
Jun 4, 1992
priority date (Note) -
Expired
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Abstract
Novel methods and compositions are provided for introducing a gene capable of modulating the genotype and phenotype into two or more tissues following systemic administration. The gene can be introduced into a mammalian host by way of an expression vector either as naked DNA or complexed to lipid carriers, particularly cationic lipid carriers. Multiple individual tissues can be transfected using naked DNA. Using a DNA:lipid carrier complex, multiple tissues and cell types can be transfected. The techniques and compositions find use in the palliation or treatment of any of a variety of genetic-based disorders.
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