Molecular recognition at surfaces derivatized with self-assembled monolayers
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United States of America Patent
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Oct 26, 2004
Grant Date -
Apr 11, 2002
app pub date -
Jul 25, 2001
filing date -
Sep 26, 1994
priority date (Note) -
Expired
status (Latency Note)
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Abstract
An article suitable for use as a biosensor includes a molecule of a formula X--R--Ch adhered to a surface of the article as part of a self-assembled monolayer. X is a functionality that adheres to the surface, R is a spacer moiety, and Ch is a chelating agent. A metal ion can be coordinated by the chelating agent, and a polyamino acid-tagged biological binding partner of a target biological molecule coordinated to the metal ion. A method of the invention involves bringing the article into contact with a medium containing or suspected of containing the target biological molecule and allowing the biological molecule to biologically bind to the binding partner. The article is useful particularly as a surface plasmon resonance chip.
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