US Patent No: 6,815,184

Number of patents in Portfolio can not be more than 2000

Expression of biologically active polypeptide in duckweed

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ALSO PUBLISHED AS: 20020088027
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Abstract

Methods, nucleic acid sequences, and transformed duckweed plant or duckweed nodule cultures for the expression and the secretion of biologically active polypeptides from genetically engineered duckweed are provided. Expression of recombinant polypeptides in duckweed is improved by modifying the nucleotide sequence of the expression cassette encoding the polypeptide for improved expression in duckweed. Recovery of biologically active polypeptides from duckweed is improved by linking the biologically active polypeptide to a signal peptide that directs the secretion of the polypeptide into the culture medium.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
SYNTHON BIOPHARMACEUTICALS B.V.6503 GN, NL16

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dickey, Lynn Cary, NC 12 37
Gasdaska, John Carrboro, NC 10 36
Stomp, Anne-Marie Raleigh, NC 12 92

Cited Art

Patent Info (Count) # Cites Year
 
CALGENE, INC. (2)
4,956,282 Mammalian peptide expression in plant cells 134 1985
5,629,175 Molecular farming 18 1995
 
CALGENE LLC (1)
6,096,547 Method and transgenic plant for producing mammalian peptides 9 1998
 
NEW JERSEY, UNIVERSITY OF, RUTGERS, STATE, BOARD OF TRUSTEES, THE (1)
6,096,546 Methods for recovering polypeptides from plants and portions thereof 12 1998
 
NORTH CAROLINA STATE UNIVERSITY (1)
6,040,498 Genetically engineered duckweed 15 1998
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
5,994,628 Process for protein production in plants 14 1995
 
Union Camp Corporation (1)
5,850,032 Method for production of plant biological products in precocious neomorphic embryoids 25 1994
 
VENTRIA BIOSCIENCE (1)
6,066,781 Production of mature proteins in plants 16 1998
 
WASHINGTON STATE UNIVERSITY (1)
6,020,169 Production of secreted foreign polypeptides in plant cell culture 6 1998

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
ROCHE GLYCART AG (7)
7,722,867 Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof 3 2006
7,662,377 Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof 4 2007
7,846,432 Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof 3 2007
7,727,741 Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof 2 2007
8,088,380 Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof 1 2010
8,097,436 Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof 1 2010
8,273,328 Antigen binding molecules that bind EGFR, vectors encoding same, and uses thereof 0 2011
 
SYNTHON BIOPHARMACEUTICALS B.V. (5)
8,022,270 Expression of biologically active polypeptides in duckweed 0 2003
7,959,910 C-terminally truncated interferon alpha variants 0 2004
7,659,445 Expression of plasminogen and microplasminogen in duck weed 0 2005
8,017,836 Expression of plasminogen and microplasminogen in duckweed 0 2009
8,182,803 C-terminally truncated interferon alpha variants 0 2011
 
PROTALIX LTD. (3)
7,951,557 Human lysosomal proteins from plant cell culture 2 2007
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8,227,230 Human lysosomal proteins from plant cell culture 0 2011
 
STRYKER NV OPERATIONS LIMITED (2)
7,942,925 Implantable intraluminal device and method of using same in treating aneurysms 2 2009
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BIOLEX THERAPEUTICS (1)
8,394,384 Recombinant avian influenza vaccine and uses thereof 0 2009
 
BIOLEX THERAPEUTICS, INC. (1)
8,137,661 Controlled release interferon drug products and treatment of HCV infections using same 0 2008
 
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MIDCAP FINANCIAL SBIC LP (1)
7,915,483 C-terminally truncated interferon 0 2007
 
NORTH CAROLINA STATE UNIVERSITY (1)
7,161,064 Method for producing stably transformed duckweed using microprojectile bombardment 5 2002

Maintenance Fees

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11.5 Year Payment $7400.00 $3700.00 $1850.00 May 9, 2016
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Surcharge - 11.5 year - Late payment within 6 months $160.00 $80.00 $40.00
Surcharge after expiration - Late payment is unavoidable $700.00 $350.00 $175.00
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