Methods for administration of paclitaxel
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United States of America Patent
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Dec 7, 2004
Issued Date -
N/A
app pub date -
Jan 23, 2003
filing date -
Oct 25, 1999
priority date (Note) -
Expired
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Abstract
Methods are provided for using paclitaxel for treating diseases associated with abnormal cell proliferation and angiogenesis. In particular, methods are provided for administration of paclitaxel formulated with vitamin E derivatives such as d-.alpha.-tocopherol polyethylene glycol succinate to a cancer patient. By administering to a patient paclitaxel in a vehicle containing a solubilizer other than Cremophor, acute hypersensitivity caused by Cremophor can be avoided and therapeutic index of paclitaxel may also be increased through potentiation of anti-neoplastic effects by the vitamin E derivatives.
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