Stable bactericidal/permeability-increasing protein products and pharmaceutical compositions containing the same
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United States of America Patent
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Dec 7, 2004
Grant Date -
Jun 12, 2003
app pub date -
Jul 16, 2002
filing date -
Feb 2, 1993
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.
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