Combinatorial protecting group strategy for multifunctional molecules
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United States of America Patent
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Dec 7, 2004
Grant Date -
Oct 16, 2003
app pub date -
Jul 2, 1999
filing date -
Apr 17, 1996
priority date (Note) -
Expired
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Abstract
The use of protection schemes and solid phase synthesis reactions to generate molecules of core structure M, which have a plurality of moieties, each of which can be individually deprotected or subsequently derivatized are provided. In one process, M is a multifunctional low molecular weight compound, such as a saccharide, aminosugar, deoxysugar, nucleoside, nucleotide, coenzyme, amino acid, lipid, steroid, vitamin, hormone, alkaloid, or small molecule drug. In another process, M is an oligomeric compound, such as an oligosaccharide, oligonucleotide, peptide or protein.
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