Systems, methods, and compositions for achieving closure of vascular puncture sites
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United States of America Patent
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-
Dec 14, 2004
Grant Date -
Dec 13, 2001
app pub date -
Feb 9, 2001
filing date -
Nov 6, 1998
priority date (Note) -
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status (Latency Note)
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Abstract
Systems, methods, and compositions achieve rapid closure of vascular puncture sites. The systems and methods form a vascular closure composition by mixing together a first component, a second component, and a buffer material. The first component includes an electrophilic polymer material having a functionality of at least three. The second component includes a nucleophilic material that, when mixed with the first component within a reaction pH range of between 7 to 9, cross-links with the first component to form a non-liquid, three-dimensional barrier. The buffer material has a pH within the reaction pH range. The systems and methods apply the composition to seal a vascular puncture site.
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