Nucleosides having bicyclic sugar moiety
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United States of America Patent
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Dec 21, 2004
Grant Date -
Feb 6, 2003
app pub date -
Apr 30, 2002
filing date -
May 26, 1998
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Abstract
Conformationally restricted 2', 4'-bridged nucleoside analogues are described herein. The compounds can be prepared by cyclization at C2' and C4' of nucleosides through a linker or linking molecule. These novel nucleosides have a desired, locked sugar pucker and are potentially useful as pharmaceutical ingredients, and especially for use in treatment of HCV.
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