Compositions and methods for generating chimeric heteromultimers
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United States of America Patent
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Dec 21, 2004
Grant Date -
Feb 6, 2003
app pub date -
Aug 1, 2001
filing date -
Aug 1, 2001
priority date (Note) -
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Abstract
The present invention provides a technique for specific assembly of monomeric polypeptides to form a heteromultimer. This technique is particularly useful for generating a genetically diverse repertoire of heteromultimers such as antigen-binding units. The invention also provides both non-single-chain and single-chain antigen-binding units that are assembled by the technique described herein. The present invention also provides recombinant polynucleotides, vectors, host cells, and kits for producing the subject antigen-binding units. Further provided by the invention are methods of using the subject antigen-binding units.
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