Stable amorphous amifostine compositions and methods for the preparation of same
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United States of America Patent
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Jan 11, 2005
Grant Date -
Oct 10, 2002
app pub date -
Mar 29, 2002
filing date -
Nov 16, 1998
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Abstract
The present invention relates to a sterile, stable dosage forms suitable for reconstitution and parenteral administration to a patient, said dosage form comprising an amorphous aminoalkyl dihydrogen phosphorothioate, and of amifostine in particular. The invention further relates to a method of preparing such a dosage form, which typically exhibits enhanced thermal stability as compared to existing vacuum dried amorphous amifostine.
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