Importance

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Abstract

The present invention relates to a method of administering a compound of Formula I: ##STR1## wherein R.sup.1 is hydrogen or C.sub.1-6 -alkyl; R.sup.2 is C.sub.1-6 -alkyl or adamantyl; R.sup.3 is C.sub.1-6 -alkyl or hydroxy; or R.sup.2 and R.sup.3 taken together are --(CR.sup.6 R.sup.7).sub.n --; R.sup.4 is C.sub.2-8 -alkyl, C.sub.2-8 -alkenyl, C.sub.2-8 -alkynyl, --OCH.sub.2 R.sup.5 or C.sub.2-8 -alkanoyl, or hydrogen when R.sup.3 is hydroxy; R.sup.5 is C.sub.1-6 -alkyl, C.sub.2-6 -alkenyl or C.sub.2-6 -alkynyl; R.sup.6 and R.sup.7 are hydrogen or C.sub.1-6 -alkyl; Y is oxygen or sulfur; and n is 3, 4, or 5, or a pharmaceutically acceptable salts of carboxylic acid of formula I, wherein said method comprises the step of admixing said compound in solid form with a topical carrier to form a topical formulation within seven days prior to first topical administration of said compound.

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First Claim