Therapeutic compositions for treating infection by Lawsonia spp.

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United States of America Patent

PATENT NO 6846487
APP PUB NO 20030103999A1
SERIAL NO

10010160

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates generally to therapeutic compositions for the treatment and/or prophylaxis of intestinal disease conditions in animals and birds caused or exacerbated by Lawsonia intracellularis or similar or otherwise related microorganism. In particular, the present invention provides a novel gene derived from Lawsonia intracellularis, which encodes an immunogenic polypeptide that is particularly useful as an antigen in a vaccine preparation for conferring humoral immunity against Lawsonia intracellularis and related pathogens in animal hosts, wherein said polypeptide is selected from the group consisting of flhB, fliR, ntrC, glnH, motA, motB, tlyC, ytfM, and ytfN polypeptides, or a homologue, analogue or derivative of any one or more of said polypeptides. The present invention is also directed to methods for the treatment and/or prophylaxis of such intestinal disease conditions and to diagnostic agents and procedures for detecting Lawsonia intracellularis or similar or otherwise related microorganisms.

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Patent Owner(s)

Patent OwnerAddress
PFIZER INC235 EAST 42ND STREET NEW YORK NY 10017
AGRICULTURE VICTORIA SERVICES PTY LTDBUNDOORA VIC 3083
AUSTRALIAN PORK LIMITEDL 2 2 BRISBANE AVE BARTON ACT 2600 AUSTRALIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Good, Robert Trygve Romsey, AU 2 0
King, Kendall Wayne Waterford, CT 6 11
Rosey, Everett Lee Preston, CT 6 16
Strugnell, Richard Anthony Hawthorn, AU 3 3

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