Methods of optimizing antibody variable region binding affinity
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United States of America Patent
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Feb 1, 2005
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N/A
app pub date -
Nov 4, 1999
filing date -
Oct 14, 1999
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Abstract
The invention provides a method of conferring donor CDR binding affinity onto an antibody acceptor variable region framework. The invention also provides a method of simultaneously grafting and optimizing the binding affinity of a variable region binding fragment. A method of optimizing the binding affinity of an antibody variable region is also provided.
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