Protective recombinant Haemophilus influenzae high molecular weight proteins
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United States of America Patent
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Feb 1, 2005
Grant Date -
Jul 17, 2003
app pub date -
Dec 11, 2002
filing date -
Oct 7, 1998
priority date (Note) -
Expired
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Abstract
Protective high molecular weight (HMW) proteins are produced recombinantly by expression from E. coli by using a promoter effective in E. coli and a nucleic acid molecule which contains a modified operon of a non-typeable strain of Haemophilus. The modified operon contains the portion only of the A region which encodes the mature HMW protein and the complete B and C regions of the operon. Enhanced levels of expression of the HMW proteins can be achieved by including the E. coli cer gene, a further copy of the portion of the A region of the operon encoding the mature protein or both in the expression vector. Nucleotide and deduced amino acid sequences of the hmw1 and hmw2 genes and HMW1 and HMW2 proteins, respectively of several non-typeable Haemophilus influenzae strain have been identified.
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