Magnetic field enhanced hybridization of target molecules to immobilized probes
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United States of America Patent
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Feb 8, 2005
Grant Date -
Nov 7, 2002
app pub date -
Nov 19, 2001
filing date -
May 14, 1999
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Abstract
The invention provides a method for increasing the hybridization rate of nucleic acids in a nucleic acid assay by labeling nucleic acid molecules with paramagnetic labels and activating a magnetic field inducing rapid migration of the labeled molecules to a solid support, where the labeled molecule hybridizes with its complementary pair. The paramagnetic label may be present on the target nucleic acid or the probe nucleic acid, depending upon whether the target or probe are the immobile phase.
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