Macrophage-infecting parasites expressing a granulocyte macrophage colony stimulated factor
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United States of America Patent
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Feb 15, 2005
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app pub date -
Sep 16, 1997
filing date -
Sep 13, 1996
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Abstract
Strains of Leishmania and other macrophage-infecting parasites are provided which express the GM-CSF gene which are useful in treating hosts infected by the parasite and in protecting hosts against disease caused by infection of hosts by parasites. The parasites are reduced in their ability to infect or survive in macrophages and hence are attenuated. At least one gene of the parasite contributing to the virulence thereto may be functionally disabled. The attenuated strains may be used for administration to a host (a) to treat a host infected by Leishmania or (b) to confer protection against disease caused by a virulent Leishmania strain, or as a diagnostic reagent.
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