Phage antibodies

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United States of America Patent

PATENT NO 6858384
APP PUB NO 20020132228A1
SERIAL NO

09865048

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Peripheral blood leucocytes incubated with a semi-synthetic phage antibody library and fluorochrome-labeled CD3 and CD20 antibodies were used to isolate human single chain Fv antibodies specific for subsets of blood leucocytes by flow cytometry. Isolated phage antibodies showed exclusive binding to the subpopulation used for selection or displayed additional binding to a restricted population of other cells in the mixture. At least two phage antibodies appeared to display hithereto unknown staining patterns of B lineage cells. This approach provides a subtractive procedure to rapidly obtain human antibodies against known and novel surface antigens in their native configuration, expressed on phenotypically defined subpopulations of cells. Importantly, this approach does not depend on immunization procedures or the necessity to repeatedly construct phage antibody libraries.

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Patent Owner(s)

Patent OwnerAddress
U-BISYS B VHEIDELBERGLAAN 100 UTRECHT NL-3584 CX

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Logtenberg, Ton Utrecht, NL 58 1068
Terstappen, Leon W M M Huntingdon Valley, PA 41 2060

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