Polymer matrix containing catalase co-immobilized with analytic enzyme that generates hydrogen peroxide
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United States of America Patent
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Feb 22, 2005
Grant Date -
Jan 17, 2002
app pub date -
Apr 2, 2001
filing date -
May 11, 1999
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Expired
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Abstract
Hydrogels containing catalase co-immobilized with an analyte-sensitive enzyme such as glucose oxidase are disclosed. The hydrogels may be pH-sensitive, and preferably are thin and lightly crosslinked. The catalase is present in concentrations ranging generally from 100 units/ml to about 1000 units/ml. These hydrogels have much faster swelling response times as compared to hydrogels without catalase, and are useful in biosensors and analyte-responsive drug delivery devices. The hydrogels also have an increased useful life, due to protection of the immobilize analyte-sensitive enzyme from degradation by hydrogen peroxide.
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